TBC1D1 and TNNC2

Data Source:
BioGRID (two hybrid)

		TBC1D1	TNNC2
Description		TBC1 domain family member 1	troponin C2, fast skeletal type
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cytosol Troponin Complex
	Molecular Function	GTPase Activator Activity Protein Binding	Actin Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Intracellular Protein Transport Regulation Of Protein Localization Membrane Organization Activation Of GTPase Activity Regulation Of Cilium Assembly	Skeletal Muscle Contraction Regulation Of Muscle Contraction Muscle Filament Sliding
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane	Striated Muscle Contraction
Drugs			Felodipine Calcium Octylphenoxy polyethoxyethanol
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Crohn's disease ( 23850713 23266558) Diastolic blood pressure ( 27841878 27618452) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1	4 interacting genes: PIK3R3 TBC1D1 TNNI2 TNNI3
Entrez ID		23216	7125
HPRD ID		18161	08929
Ensembl ID		ENSG00000065882	ENSG00000101470
Uniprot IDs		B9A6J6 Q6PJJ8 Q86TI0 Q8NC59	C9J7T9 P02585
PDB IDs		3QYE
Enriched GO Terms of Interacting Partners?
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