KDM4B and MED10

Data Source:
HPRD (two hybrid)

		KDM4B	MED10
Description		lysine demethylase 4B	mediator complex subunit 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Ubiquitin Ligase Complex Chromatin Nucleoplasm Mediator Complex
	Molecular Function	Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding Histone Demethylase Activity (H3-K36 Specific)	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Remodeling Histone H3-K9 Demethylation Histone H3-K36 Demethylation	Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Estrogen-dependent gene expression	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontitis (CDC/AAP) ( 24024966) Pulse pressure ( 30578418) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: H3-5 MED10	12 interacting genes: ABI2 ARHGDIG ESR1 ESR2 FUCA1 HNF4A KDM4B MOB4 NAP1L1 PEBP1 SYCE1L TRIM45
Entrez ID		23030	84246
HPRD ID		11056	14680
Ensembl ID		ENSG00000127663	ENSG00000133398
Uniprot IDs		A0A0C4DFL8 F5GX28 O94953	Q9BTT4
PDB IDs		4LXL 4UC4
Enriched GO Terms of Interacting Partners?
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