XRN2 and MRPS10

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		XRN2	MRPS10
Description		5'-3' exoribonuclease 2	mitochondrial ribosomal protein S10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	Molecular_function
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Biological_process Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2	1 interacting genes: XRN2
Entrez ID		22803	55173
HPRD ID		10309	14775
Ensembl ID		ENSG00000088930	ENSG00000048544
Uniprot IDs		B4DZC3 Q9H0D6	A0A024RD03 B4DP77 P82664
PDB IDs			3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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