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XRN2 and EXOSC10
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
XRN2
EXOSC10
Description
5'-3' exoribonuclease 2
exosome component 10
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Membrane
Aggresome
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Membrane
Transcriptionally Active Chromatin
Molecular Function
3'-5'-exoribonuclease Activity
Transcription Termination Site Sequence-specific DNA Binding
RNA Binding
Nuclease Activity
5'-3' Exoribonuclease Activity
Protein Binding
5'-3' Exonuclease Activity
Identical Protein Binding
Metal Ion Binding
Nucleotide Binding
3'-5'-exoribonuclease Activity
RNA Binding
Single-stranded RNA Binding
Exoribonuclease Activity
Protein Binding
Telomerase RNA Binding
Biological Process
DNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process
DNA-templated Transcription, Termination
RRNA Processing
RNA Processing
MRNA Processing
RNA Catabolic Process
Spermatogenesis
RNA Metabolic Process
Hippocampus Development
Neuron Differentiation
Retina Development In Camera-type Eye
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Maturation Of 5.8S RRNA
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Dosage Compensation By Inactivation Of X Chromosome
Negative Regulation Of Telomere Maintenance Via Telomerase
Nuclear MRNA Surveillance
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent SnoRNA Catabolic Process
Nuclear Polyadenylation-dependent SnRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent CUT Catabolic Process
Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process
Histone MRNA Catabolic Process
Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription
Polyadenylation-dependent SnoRNA 3'-end Processing
Regulation Of Telomerase RNA Localization To Cajal Body
Pathways
Association of TriC/CCT with target proteins during biosynthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Autism spectrum disorder (
30804558
)
Lupus nephritis in systemic lupus erythematosus (
24925725
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Red cell distribution width (
32888494
)
Beard thickness (
26926045
)
Heel bone mineral density (
30598549
)
Intraocular pressure (
29617998
)
Interacting Genes
28 interacting genes:
ALDH1B1
ATRN
COMT
CRY2
CSNK2A1
CTSC
DXO
DYNLT1
EEF1A1
EIF3L
EIF5A
EIF6
ERG
EXOSC10
EXOSC8
LCN2
LSM3
MOCS3
MRPL4
MRPS10
PLEKHF2
PRAME
PSMA3
TARDBP
TIPARP
TOLLIP
TTC23
UPF2
37 interacting genes:
ALDH1B1
B9D1
CHPF
CIB1
DIS3
DXO
EIF3M
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
FERMT3
FOXRED1
IMMT
LCAT
LSM2
LSM8
MPHOSPH6
NOMO1
NOMO2
PALS2
PTGES2
RPE
RUVBL2
SCRIB
SKIV2L
SSRP1
SUMO2
TARDBP
TOX4
TTN
UPF2
USP16
USP21
XRN1
XRN2
Entrez ID
22803
5394
HPRD ID
10309
16180
Ensembl ID
ENSG00000088930
ENSG00000171824
Uniprot IDs
B4DZC3
Q9H0D6
Q01780
PDB IDs
2CPR
3SAF
3SAG
3SAH
6D6Q
6D6R
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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