XRN2 and EIF5A

Data Source:
HPRD (two hybrid)

		XRN2	EIF5A
Description		5'-3' exoribonuclease 2	eukaryotic translation initiation factor 5A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding Protein N-terminus Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	MRNA Export From Nucleus Translational Elongation Protein Export From Nucleus Nucleocytoplasmic Transport Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol	Hypusine synthesis from eIF5A-lysine
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Venous thromboembolism ( 31420334)
Interacting Genes		28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2	17 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP STUB1 SUMO2 TGM2 XPO1 XPO4 XRN2
Entrez ID		22803	1984
HPRD ID		10309	02555
Ensembl ID		ENSG00000088930	ENSG00000132507
Uniprot IDs		B4DZC3 Q9H0D6	P63241
PDB IDs			1FH4 3CPF 5DLQ
Enriched GO Terms of Interacting Partners?
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