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FGF7 and COL1A1
Data Source:
HPRD
(in vitro)
FGF7
COL1A1
Description
fibroblast growth factor 7
collagen type I alpha 1 chain
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Golgi Apparatus
Extracellular Region
Collagen Type I Trimer
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Apparatus
Secretory Granule
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Fibroblast Growth Factor Receptor Binding
Type 2 Fibroblast Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemoattractant Activity
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Identical Protein Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermis Development
Response To Wounding
Animal Organ Morphogenesis
Mesenchymal Cell Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Keratinocyte Proliferation
Cell Differentiation
Lung Development
Regulation Of Cell Migration
Hair Follicle Morphogenesis
Actin Cytoskeleton Reorganization
Protein Localization To Cell Surface
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Keratinocyte Migration
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Branching Involved In Salivary Gland Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Secretion By Lung Epithelial Cell Involved In Lung Growth
Skeletal System Development
Ossification
Blood Vessel Development
Osteoblast Differentiation
Intramembranous Ossification
Endochondral Ossification
Blood Coagulation
Visual Perception
Sensory Perception Of Sound
Response To Mechanical Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Cell-substrate Adhesion
Protein Transport
Platelet Activation
Extracellular Matrix Organization
Collagen Fibril Organization
Positive Regulation Of Cell Migration
Response To Corticosteroid
Response To Estradiol
Collagen Biosynthetic Process
Protein Localization To Nucleus
Tooth Mineralization
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Response To Drug
Response To Hydrogen Peroxide
Response To Peptide Hormone
Skin Development
Skin Morphogenesis
Cellular Response To Fibroblast Growth Factor Stimulus
Tooth Eruption
Positive Regulation Of Transcription, DNA-templated
Embryonic Skeletal System Development
Regulation Of Immune Response
Leukocyte Migration
Response To CAMP
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Cartilage Development Involved In Endochondral Bone Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Vitamin E
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Fluoride
Pathways
PI3K Cascade
PIP3 activates AKT signaling
FGFR2b ligand binding and activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR2
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
Negative regulation of FGFR2 signaling
Signaling by FGFR2 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
RUNX2 regulates osteoblast differentiation
Collagen chain trimerization
Drugs
Collagenase clostridium histolyticum
Halofuginone
Clove oil
Vonicog Alfa
Von Willebrand Factor Human
Diseases
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Infantile cortical hyperostosis; Caffey disease
Osteogenesis imperfecta
GWAS
Blood protein levels (
30072576
29875488
)
Lung adenocarcinoma (
28604730
)
Thyroid hormone levels (
23408906
)
Thyroid volume (
21565293
)
Blood cell traits (multivariate analysis) (
31080455
)
Breast cancer (
17903305
)
Heel bone mineral density (
30598549
)
Response to taxane treatment (docetaxel) (
23006423
)
Interacting Genes
14 interacting genes:
COL1A1
COL2A1
COL3A1
COL6A1
DESI1
DUSP3
FGFR1
FGFR2
FGFR3
FGFR4
HSPG2
NRP1
PTX3
UBQLN1
40 interacting genes:
ATP13A2
BARD1
BGN
BMP1
BRCA1
CAPN1
CD36
CD44
CD93
CDC42
COL7A1
DCN
DDR2
FGF7
FN1
HTRA1
IGFBP3
ITGA2
ITGA5
KEAP1
MAG
MATN2
MCPH1
MMP2
MMP9
NID1
NID2
P4HB
PAK1
PDGFA
PDGFB
PKD1
PRELP
SPARC
TGFBI
THBS1
TMPRSS6
TXN
UBC
VWF
Entrez ID
2252
1277
HPRD ID
01022
00362
Ensembl ID
ENSG00000140285
ENSG00000108821
Uniprot IDs
P21781
P02452
PDB IDs
1Q7D
2LLP
3EJH
3GXE
5CTD
5CTI
5CVA
5CVB
5K31
5OU8
5OU9
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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