THSD7A and LYVE1

Data Source:
BioGRID (two hybrid)

		THSD7A	LYVE1
Description		thrombospondin type 1 domain containing 7A	lymphatic vessel endothelial hyaluronan receptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane Cell Projection	Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Hyaluronic Acid Binding Signaling Receptor Activity
	Biological Process	Angiogenesis Cell Differentiation Actin Cytoskeleton Reorganization	Cell-matrix Adhesion Response To Wounding Anatomical Structure Morphogenesis Hyaluronan Catabolic Process
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Hyaluronan uptake and degradation
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Alzheimer's disease (APOE e4 interaction) ( 25778476) Bipolar disorder ( 31043756) Cataracts (operation) ( 31816047) Coronary artery disease ( 29472232) Dental caries (decayed, missing and filled teeth) ( 31533690) End-stage kidney disease ( 31178898) Facial emotion recognition (angry faces) ( 28608620) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935) Household income (MTAG) ( 31844048) Idiopathic dilated cardiomyopathy ( 29495422) Intraocular pressure ( 29785010 31959993) Iron status biomarkers (total iron binding capacity) ( 28334935) Lead levels in blood ( 25820613) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (antiglaucoma preparations and miotics) ( 31015401) Refractive error ( 32231278) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Resting-state electroencephalogram vigilance ( 29703947) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009) Tourette syndrome ( 22889924)	Blood protein levels ( 30072576)
Interacting Genes		14 interacting genes: AQP6 ARL13B ASAP2 CD33 COMT ELOVL5 GOLM1 HSD17B13 LHFPL1 LYVE1 SCN3B SKIL TMUB2 VMA21	26 interacting genes: AIG1 AQP10 CLCN7 CYSRT1 EMP3 KRT34 KRTAP10-3 KRTAP10-8 KRTAP12-3 KRTAP6-2 KRTAP9-2 NBPF19 NINJ2 NOTCH2NLA NRSN1 PDGFB PIGF SERP2 SLC30A2 SLC38A7 SLC41A2 THSD7A THSD7B UBE2J1 VEGFA YIPF6
Entrez ID		221981	10894
HPRD ID		19401	05753
Ensembl ID		ENSG00000005108	ENSG00000133800
Uniprot IDs		Q9UPZ6	B2R672 Q9Y5Y7
PDB IDs
Enriched GO Terms of Interacting Partners?
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