LYVE1 and CLCN7

Data Source:
BioGRID (two hybrid)

		LYVE1	CLCN7
Description		lymphatic vessel endothelial hyaluronan receptor 1	chloride voltage-gated channel 7
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Exosome	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Hyaluronic Acid Binding Signaling Receptor Activity	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Cell-matrix Adhesion Response To Wounding Anatomical Structure Morphogenesis Hyaluronan Catabolic Process	Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Hyaluronan uptake and degradation	Stimuli-sensing channels
Drugs
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Blood protein levels ( 30072576)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)
Interacting Genes		26 interacting genes: AIG1 AQP10 CLCN7 CYSRT1 EMP3 KRT34 KRTAP10-3 KRTAP10-8 KRTAP12-3 KRTAP6-2 KRTAP9-2 NBPF19 NINJ2 NOTCH2NLA NRSN1 PDGFB PIGF SERP2 SLC30A2 SLC38A7 SLC41A2 THSD7A THSD7B UBE2J1 VEGFA YIPF6	17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B
Entrez ID		10894	1186
HPRD ID		05753	04103
Ensembl ID		ENSG00000133800	ENSG00000103249
Uniprot IDs		B2R672 Q9Y5Y7	P51798
PDB IDs			7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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