THSD7A and ASAP2

Data Source:
BioGRID (two hybrid)

		THSD7A	ASAP2
Description		thrombospondin type 1 domain containing 7A	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane Cell Projection	Plasma Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Cell Differentiation Actin Cytoskeleton Reorganization	Positive Regulation Of GTPase Activity
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Alzheimer's disease (APOE e4 interaction) ( 25778476) Bipolar disorder ( 31043756) Cataracts (operation) ( 31816047) Coronary artery disease ( 29472232) Dental caries (decayed, missing and filled teeth) ( 31533690) End-stage kidney disease ( 31178898) Facial emotion recognition (angry faces) ( 28608620) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935) Household income (MTAG) ( 31844048) Idiopathic dilated cardiomyopathy ( 29495422) Intraocular pressure ( 29785010 31959993) Iron status biomarkers (total iron binding capacity) ( 28334935) Lead levels in blood ( 25820613) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (antiglaucoma preparations and miotics) ( 31015401) Refractive error ( 32231278) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Resting-state electroencephalogram vigilance ( 29703947) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009) Tourette syndrome ( 22889924)	Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 30804561) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)
Interacting Genes		14 interacting genes: AQP6 ARL13B ASAP2 CD33 COMT ELOVL5 GOLM1 HSD17B13 LHFPL1 LYVE1 SCN3B SKIL TMUB2 VMA21	14 interacting genes: APC ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 SH3KBP1 THSD7A
Entrez ID		221981	8853
HPRD ID		19401	04820
Ensembl ID		ENSG00000005108	ENSG00000151693
Uniprot IDs		Q9UPZ6	O43150
PDB IDs
Enriched GO Terms of Interacting Partners?
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