F8 and F9

Data Source:
HPRD (in vitro)

		F8	F9
Description		coagulation factor VIII	coagulation factor IX
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Copper Ion Binding Protein Binding Oxidoreductase Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway COPII Vesicle Coating	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Blood Coagulation, Intrinsic Pathway Zymogen Activation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma carboxylation, hypusine formation and arylsulfatase activation COPII-mediated vesicle transport Cargo concentration in the ER Defective factor IX causes thrombophilia Defective F8 accelerates dissociation of the A2 domain Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Defective F8 binding to the cell membrane Defective cofactor function of FVIIIa variant Defective F8 secretion Defective F9 variant does not activate FX Defective F8 sulfation at Y1699	Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX Defective F9 secretion Defective F9 activation Defective gamma-carboxylation of F9
Drugs		Drotrecogin alfa Coagulation Factor IX (Recombinant) TB-402 Thrombin Protein C Human thrombin Thrombin alfa Vonicog Alfa Von Willebrand Factor Human Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol Damoctocog alfa pegol	Antihemophilic factor, human recombinant Menadione TTP889 Turoctocog alfa Kappadione Coagulation factor VII human Antihemophilic factor human Emicizumab Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)	Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)	Venous thromboembolism ( 31676865)
Interacting Genes		17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF	5 interacting genes: F2 F7 F8 GGCX LRP1
Entrez ID		2157	2158
HPRD ID		02384	02385
Ensembl ID		ENSG00000185010	ENSG00000101981
Uniprot IDs		P00451	P00740
PDB IDs		1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF2	1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM 5F84 5F85 5F86 5JB8 5JB9 5JBA 5JBB 5JBC 5TNO 5TNT 5VYG 6MV4 6RFK 6X5J 6X5L 6X5P
Enriched GO Terms of Interacting Partners?
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