F9

Description		coagulation factor IX
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Blood Coagulation, Intrinsic Pathway Zymogen Activation
Pathways		Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX Defective F9 secretion Defective F9 activation Defective gamma-carboxylation of F9
Drugs		Antihemophilic factor, human recombinant Menadione TTP889 Turoctocog alfa Kappadione Coagulation factor VII human Antihemophilic factor human Emicizumab Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Venous thromboembolism ( 31676865)
Interacting Genes		5 interacting genes: F2 F7 F8 GGCX LRP1
Entrez ID		2158
HPRD ID		02385
Ensembl ID		ENSG00000101981
Uniprot IDs		P00740
PDB IDs		1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM 5F84 5F85 5F86 5JB8 5JB9 5JBA 5JBB 5JBC 5TNO 5TNT 5VYG 6MV4 6RFK 6X5J 6X5L 6X5P
Enriched GO Terms of Interacting Partners?
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