F8 and PHYH

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		F8	PHYH
Description		coagulation factor VIII	phytanoyl-CoA 2-hydroxylase
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Mitochondrion Peroxisome Peroxisomal Matrix Cytosol 9+0 Non-motile Cilium
	Molecular Function	Copper Ion Binding Protein Binding Oxidoreductase Activity	Protein Binding Ferrous Iron Binding Carboxylic Acid Binding L-ascorbic Acid Binding Phytanoyl-CoA Dioxygenase Activity
	Biological Process	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway COPII Vesicle Coating	Fatty Acid Alpha-oxidation 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome Isoprenoid Metabolic Process 2-oxobutyrate Catabolic Process Methyl-branched Fatty Acid Metabolic Process
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma carboxylation, hypusine formation and arylsulfatase activation COPII-mediated vesicle transport Cargo concentration in the ER Defective factor IX causes thrombophilia Defective F8 accelerates dissociation of the A2 domain Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Defective F8 binding to the cell membrane Defective cofactor function of FVIIIa variant Defective F8 secretion Defective F9 variant does not activate FX Defective F8 sulfation at Y1699	Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Drotrecogin alfa Coagulation Factor IX (Recombinant) TB-402 Thrombin Protein C Human thrombin Thrombin alfa Vonicog Alfa Von Willebrand Factor Human Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol Damoctocog alfa pegol	Antihemophilic factor, human recombinant Ascorbic acid Lonoctocog alfa Moroctocog alfa
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)	Refsum disease; Heredopathia atactica polyneuritiformis
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)
Interacting Genes		17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF	11 interacting genes: ACSL6 APP F8 FAM9B FKBP4 MAGEA11 PATJ PEX7 PHYHIP SIRPA TOM1L1
Entrez ID		2157	5264
HPRD ID		02384	03609
Ensembl ID		ENSG00000185010	ENSG00000107537
Uniprot IDs		P00451	O14832
PDB IDs		1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF2	2A1X
Enriched GO Terms of Interacting Partners?
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