ERCC1 and USHBP1

Data Source:
BioGRID (two hybrid)

		ERCC1	USHBP1
Description		ERCC excision repair 1, endonuclease non-catalytic subunit	USH1 protein network component harmonin binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	Protein Binding PDZ Domain Binding
	Biological Process	Meiotic Mismatch Repair Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation Response To Oxidative Stress Spermatogenesis Response To Nutrient Cell Population Proliferation Male Gonad Development UV Protection Response To Sucrose Response To X-ray Multicellular Organism Aging Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Post-embryonic Hemopoiesis Multicellular Organism Growth Response To Immobilization Stress Interstrand Cross-link Repair Isotype Switching Response To Cadmium Ion Oogenesis Embryonic Organ Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Telomeric DNA-containing Double Minutes Formation Global Genome Nucleotide-excision Repair UV-damage Excision Repair Replicative Senescence T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Simvastatin-induced myopathy ( 31220337)	Mitochondrial DNA copy number ( 30704525)
Interacting Genes		18 interacting genes: APP CHRM5 ERCC4 GAS8 KIF11 MKRN3 RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA	234 interacting genes: ABHD11 ABI2 ABLIM1 ACMSD AKAP9 ANKRD33 ANKRD36BP1 ARFIP2 ARMC5 ARNT2 ASB15 ATP5PO BCAS2 BCL10 BCL2L11 BET1 BEX2 BEX3 BFSP1 BFSP2 BICRAL BLOC1S1 BLZF1 BORCS6 BRAT1 BRPF1 C1orf109 C1orf216 C21orf58 CBY2 CCDC103 CCDC116 CCDC120 CCDC121 CCDC146 CCDC148 CCDC187 CCDC196 CCDC197 CCDC22 CCDC24 CCDC28A CCDC33 CCDC42 CCDC87 CCHCR1 CCNK CDC37 CDC5L CDKN1A CENPP CEP63 CEP68 CFAP206 CHCHD3 CNNM3 COPS4 COPS6 COPS8 CTNNA3 CTNNBIP1 CTTNBP2NL CYTH4 DCTN2 DCTN3 DEPP1 DEUP1 DTNB DYDC1 EIF4E2 ENKD1 ERCC1 EXOC7 EXOC8 FAM107A FAM110A FAM124B FAM161B FANCG FATE1 FBF1 FCHSD2 FCRL5 FTL GAS8 GATAD2B GCC1 GEM GFI1B GIT2 GMCL2 GNG4 GOLGA6L9 GOLGA8EP GOLGA8F GPSM1 GPSM3 GTF2H1 HAUS1 HAUS8 HGS HMG20A HMG20B HYI IFT20 IL16 IMP3 ING3 INPP1 INTS4 ITGB3BP KANK2 KANSL1 KIAA0753 KLC3 KLC4 KLHL38 KLHL42 KPNA2 KRT14 KRT15 KRT16 KRT19 KRT20 KRT26 KRT27 KRT28 KRT31 KRT37 KRT38 KRT40 KRT71 KRT75 KRT79 LENG1 LINC00526 MAGEB4 MCCD1 MCM7 MCRS1 MED11 MED28 MED4 MEI4 METTL15 MIIP MKRN3 MNS1 MOS MRPS23 MXI1 MYOG MYOZ1 NCAPH2 NDC80 NDE1 NECAB2 NEFL NOC4L NUP62 ODAD3 OIP5 PARVG PAX6 PBX4 PICK1 PKN1 PKNOX2 PMF1 POLM POP5 PPP1R12C PPP1R7 PPP2R5A PPP2R5D PRC1 PRKAA2 PRR5 QARS1 RASAL2 RCOR3 RECK RIBC1 RIBC2 RINT1 RNF20 RTP5 SAPCD2 SAT1 SCNM1 SCT SEC14L4 SEMA4C SERTAD3 SH2D4A SHC3 SMARCD1 SMARCE1 SOHLH1 SPG21 SRI STX11 SYNJ2BP TASOR2 TCEANC TCHP TEKT1 THADA THOC1 TIMM13 TPRX1 TRIM54 TRIML2 TSG101 TTC23 TTC9C TTLL10 TUBGCP4 TXLNA TXLNB UBE2W UBXN11 USH1C USP2 VPS28 ZBTB42 ZFHX3 ZFYVE26 ZNF417 ZNF483 ZNF655 ZNF688 ZNF765 ZNRF2P1
Entrez ID		2067	83878
HPRD ID		00533	18276
Ensembl ID		ENSG00000012061	ENSG00000130307
Uniprot IDs		A0A024R0Q6 P07992	A0A024R7H3 B4DUE8 G8JLM4 Q8N6Y0 Q8N8Y1
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD 2MUT 6SXA 6SXB
Enriched GO Terms of Interacting Partners?
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