KHDRBS2 and TYK2

Data Source:
BioGRID (two hybrid, two hybrid)

		KHDRBS2	TYK2
Description		KH RNA binding domain containing, signal transduction associated 2	tyrosine kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding SH2 Domain Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Type I Interferon Signaling Pathway Interleukin-27-mediated Signaling Pathway
Pathways		PTK6 Regulates Proteins Involved in RNA Processing	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs			2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Tofacitinib Fostamatinib
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Chronotype ( 30696823) Corneal astigmatism ( 30306274) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Esophageal adenocarcinoma ( 27527254) Presence of antiphospholipid antibodies ( 27098658) Protein quantitative trait loci ( 18464913)	Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) COVID-19 (critical illness vs population) ( 33307546) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 25751624 32005708 19966805) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 30584014)
Interacting Genes		47 interacting genes: AEN BAHD1 BMP7 CATSPER1 CHTOP CIRBP CNNM3 DALRD3 DOCK2 EWSR1 FOXD4L3 GRAP2 GRB2 HBZ HHEX HNRNPK HNRNPLL KHDRBS3 LINC01018 LMNTD2 LNX1 MTA1 NABP1 NCOA5 NPDC1 PRMT1 PRPF31 PRR3 PSMF1 PTK6 RBM10 RBM14 RBM3 RBMX RFC3 SDCBP SPG7 SULT1A3 TMEM14B TYK2 TYMSOS YTHDC1 ZFC3H1 ZNF497 ZNF581 ZNF688 ZNF837	44 interacting genes: CBL COPS5 CRKL CYSRT1 DNM2 EIF2AK2 FHL3 FYN GHR GOLGA6L9 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP6-3 LYN PDGFRB PIK3R1 PLAUR PRDM5 PRMT5 PTAFR PTPN1 PTPN6 PTPRC RACK1 SOCS1 STAM2 STAT1 STAT2 TK1 TP53BP2 TRAF4 VAV1 XRCC5
Entrez ID		202559	7297
HPRD ID		13775	01490
Ensembl ID		ENSG00000112232	ENSG00000105397
Uniprot IDs		A0A6Q8PGH5 Q5VWX1	A0A024R7E4 P29597
PDB IDs			3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NSL 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR 6OVA 6VNS 6VNV 6VNX 6VNY
Enriched GO Terms of Interacting Partners?
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