TYK2 and STAM2

Data Source:
HPRD (in vivo, in vitro)

		TYK2	STAM2
Description		tyrosine kinase 2	signal transducing adaptor molecule 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Type 1 Angiotensin Receptor Binding	Protein Binding
	Biological Process	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Type I Interferon Signaling Pathway Interleukin-27-mediated Signaling Pathway	Intracellular Protein Transport Signal Transduction Endosomal Transport Macroautophagy Protein Deubiquitination Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS	EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Tofacitinib Fostamatinib
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) COVID-19 (critical illness vs population) ( 33307546) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 25751624 32005708 19966805) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 30584014)	Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)
Interacting Genes		44 interacting genes: CBL COPS5 CRKL CYSRT1 DNM2 EIF2AK2 FHL3 FYN GHR GOLGA6L9 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP6-3 LYN PDGFRB PIK3R1 PLAUR PRDM5 PRMT5 PTAFR PTPN1 PTPN6 PTPRC RACK1 SOCS1 STAM2 STAT1 STAT2 TK1 TP53BP2 TRAF4 VAV1 XRCC5	39 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN2 UBQLN4 USP8 VPS37C XRN1 ZC3H10
Entrez ID		7297	10254
HPRD ID		01490	05876
Ensembl ID		ENSG00000105397	ENSG00000115145
Uniprot IDs		A0A024R7E4 P29597	O75886
PDB IDs		3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NSL 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR 6OVA 6VNS 6VNV 6VNX 6VNY	1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?
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