ELF5 and NFE2

Data Source:
BioGRID (two hybrid)

		ELF5	NFE2
Description		E74 like ETS transcription factor 5	nuclear factor, erythroid 2
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GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation	Nucleosome Disassembly Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Blood Coagulation Hemostasis Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways			RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Blood protein levels ( 28240269) Metabolite levels ( 23823483)	Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 22139419 24026423) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: ACTR2 FRZB GLRX2 NFE2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4	21 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN WWP1 YAP1
Entrez ID		2001	4778
HPRD ID		05525	09030
Ensembl ID		ENSG00000135374	ENSG00000123405
Uniprot IDs		A0A087X1W9 A8K443 Q9UKW6	A8K3E0 Q16621
PDB IDs		1WWX	1LVX 2KZ5
Enriched GO Terms of Interacting Partners?
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