ELF5 and ACTR2

Data Source:
BioGRID (two hybrid)

		ELF5	ACTR2
Description		E74 like ETS transcription factor 5	actin related protein 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Extracellular Region Nucleus Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Podosome Core Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation	Establishment Or Maintenance Of Cell Polarity Associative Learning Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Response To Immobilization Stress Cellular Response To Trichostatin A Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Spindle Localization Cilium Assembly Positive Regulation Of Dendritic Spine Morphogenesis Membrane Organization Cellular Response To Interferon-gamma Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Blood protein levels ( 28240269) Metabolite levels ( 23823483)	Calcific aortic valve stenosis ( 32141789) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: ACTR2 FRZB GLRX2 NFE2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4	14 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 ELF5 ERCC6 HCLS1 IQGAP2 SHARPIN WASF1 WASF2 WASL
Entrez ID		2001	10097
HPRD ID		05525	05023
Ensembl ID		ENSG00000135374	ENSG00000138071
Uniprot IDs		A0A087X1W9 A8K443 Q9UKW6	P61160
PDB IDs		1WWX	6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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