NFE2 and TXN

Data Source:
BioGRID (two hybrid)

		NFE2	TXN
Description		nuclear factor, erythroid 2	thioredoxin
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Thioredoxin-disulfide Reductase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Protein Homodimerization Activity Protein-disulfide Reductase Activity
	Biological Process	Nucleosome Disassembly Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Blood Coagulation Hemostasis Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Glycerol Ether Metabolic Process Response To Radiation Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of DNA Binding Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Kinase B Signaling Response To Nitric Oxide Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Peptidyl-cysteine S-nitrosylation
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	Oxidative Stress Induced Senescence Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes Protein repair The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 22139419 24026423) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		21 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN WWP1 YAP1	38 interacting genes: ACTN1 ACTN4 ANKRD11 APEX1 CDKN1A COL1A1 COPS5 DDIT4L DNAJA1 DYNLT1 EGFR ERBB2 ERBB3 ERBB4 FST GFER GPRASP2 MAP3K5 MLH1 MRFAP1 MYD88 NCF4 NFE2 NFKB1 NIF3L1 NR3C1 NUP62 PTEN SERTAD3 SIAH1 SPG21 SRPK2 TEX13A TP53 TRAF2 TXNIP UCHL5 VIM
Entrez ID		4778	7295
HPRD ID		09030	01761
Ensembl ID		ENSG00000123405	ENSG00000136810
Uniprot IDs		A8K3E0 Q16621	H9ZYJ2 P10599
PDB IDs		1LVX 2KZ5	1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4LL1 4LL4 4OO4 4OO5 4POK 4POL 4POM 4PUF 4TRX 5DQY
Enriched GO Terms of Interacting Partners?
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