A2M and TTR

Data Source:
BioGRID (two hybrid)

		A2M	TTR
Description		alpha-2-macroglobulin	transthyretin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Protein-containing Complex Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Hormone Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Thyroid Hormone Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Retinoid Metabolic Process Purine Nucleobase Metabolic Process Signal Transduction Extracellular Matrix Organization Retinol Metabolic Process Neutrophil Degranulation Cellular Protein Metabolic Process Thyroid Hormone Transport
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly	Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Non-integrin membrane-ECM interactions Neutrophil degranulation Retinoid metabolism and transport Amyloid fiber formation
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc Copper Tafamidis Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Familial carpal tunnel syndrome Familial amyloidosis
GWAS		Refractive error ( 32231278)	Retinol levels ( 21878437)
Interacting Genes		96 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS	49 interacting genes: A2M ACTB AGER APOA1 ATF4 ATF5 BAG6 CDR2 CEP126 CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 ELP1 ERG28 FEZ1 GET3 GET4 HNRNPH3 HSP90AA1 HSPG2 INPP5K LRP2 MARK3 MT3 NDUFA5 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS1 RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1
Entrez ID		2	7276
HPRD ID		00072	01447
Ensembl ID		ENSG00000175899	ENSG00000118271
Uniprot IDs		P01023	E9KL36 P02766
PDB IDs		1BV8 2P9R 4ACQ	1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NBO 2NBP 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4D7B 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4HJS 4HJT 4HJU 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 4MRB 4MRC 4N85 4N86 4N87 4PM1 4PME 4PMF 4PVL 4PVM 4PVN 4PWE 4PWF 4PWG 4PWH 4PWI 4PWJ 4PWK 4QRF 4QXV 4QYA 4TKW 4TL4 4TL5 4TLK 4TLS 4TLT 4TLU 4TM9 4TNE 4TNF 4TNG 4TQ8 4TQH 4TQI 4TQP 4WNJ 4WNS 4WO0 4Y9B 4Y9C 4Y9E 4Y9F 4Y9G 4YDM 4YDN 5A6I 5AKS 5AKT 5AKV 5AL0 5AL8 5AYT 5BOJ 5CLX 5CLY 5CLZ 5CM1 5CN3 5CNH 5CR1 5DEJ 5DWP 5E23 5E4A 5E4O 5EN3 5EZP 5FO2 5FW6 5FW7 5FW8 5H0V 5H0W 5H0X 5H0Y 5H0Z 5HJG 5IHH 5JID 5JIM 5JIQ 5K1J 5K1N 5L4F 5L4I 5L4J 5L4M 5LLL 5LLV 5N5Q 5N62 5N7C 5NFE 5NFW 5OQ0 5TTR 5TZL 5U48 5U49 5U4A 5U4B 5U4C 5U4D 5U4E 5U4F 5U4G 6D0W 6E6Z 6E70 6E71 6E72 6E73 6E74 6E75 6E76 6E77 6E78 6EP1 6FFT 6FWD 6FXU 6FZL 6GR7 6GRP 6IMX 6IMY 6KGB 6R66 6R67 6R68 6R6I 6SDZ 6SUG 6SUH 6TI9 6TXV 6TXW 6XTK 7ACU
Enriched GO Terms of Interacting Partners?
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