A2M and SEPTIN8

Data Source:
BioGRID (two hybrid)

		A2M	SEPTIN8
Description		alpha-2-macroglobulin	septin 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Septin Ring Microtubule Cytoskeleton Axon Synaptic Vesicle Membrane Septin Complex Cell Division Site Presynapse
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	GTPase Activity Protein Binding GTP Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Cellular Protein Localization Regulation Of SNARE Complex Assembly Cytoskeleton-dependent Cytokinesis
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Refractive error ( 32231278)
Interacting Genes		96 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS	11 interacting genes: A2M CDK14 ESR1 JADE1 KMT2B PPHLN1 SEPTIN4 SEPTIN5 SH3GL1 SH3GL3 SPTBN1
Entrez ID		2	23176
HPRD ID		00072	12228
Ensembl ID		ENSG00000175899	ENSG00000164402
Uniprot IDs		P01023	A6NFQ9 B7ZVZ1 Q92599
PDB IDs		1BV8 2P9R 4ACQ	6UPR
Enriched GO Terms of Interacting Partners?
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