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A2M and IL1B
Data Source:
HPRD
(in vitro, in vivo)
A2M
IL1B
Description
alpha-2-macroglobulin
interleukin 1 beta
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Extracellular Region
Extracellular Space
Lysosome
Cytosol
Molecular Function
Protease Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Growth Factor Binding
Enzyme Binding
Interleukin-8 Binding
Interleukin-1 Binding
Tumor Necrosis Factor Binding
Calcium-dependent Protein Binding
Cytokine Activity
Interleukin-1 Receptor Binding
Integrin Binding
Protein Binding
Protein Domain Specific Binding
Biological Process
Negative Regulation Of Complement Activation, Lectin Pathway
Platelet Degranulation
Blood Coagulation, Intrinsic Pathway
Negative Regulation Of Endopeptidase Activity
Extracellular Matrix Disassembly
Stem Cell Differentiation
Regulation Of Small GTPase Mediated Signal Transduction
MAPK Cascade
Activation Of MAPK Activity
Fever Generation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of T Cell Mediated Immunity
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
Cell-cell Signaling
Embryo Implantation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Vascular Endothelial Growth Factor Production
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Glucose Transmembrane Transport
Smooth Muscle Adaptation
Cytokine-mediated Signaling Pathway
Hyaluronan Biosynthetic Process
Positive Regulation Of Cell Migration
Sequestering Of Triglyceride
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Fever Generation
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Prostaglandin Secretion
Response To Lipopolysaccharide
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Histone Phosphorylation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Positive Regulation Of Histone Acetylation
Positive Regulation Of Myosin Light Chain Kinase Activity
Cellular Response To Drug
Positive Regulation Of T Cell Proliferation
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Angiogenesis
Negative Regulation Of Lipid Metabolic Process
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Complement Activation
Positive Regulation Of JNK Cascade
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Protein Export From Nucleus
Positive Regulation Of Inflammatory Response
Positive Regulation Of Phagocytosis
Regulation Of Neurogenesis
Negative Regulation Of Neurogenesis
Regulation Of Insulin Secretion
Negative Regulation Of Synaptic Transmission
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Lipid Catabolic Process
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cell Division
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Cell Adhesion Molecule Production
Positive Regulation Of Calcidiol 1-monooxygenase Activity
Negative Regulation Of Adiponectin Secretion
Regulation Of ERK1 And ERK2 Cascade
Monocyte Aggregation
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Substance
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of Neuroinflammatory Response
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Gap Junction Assembly
Positive Regulation Of T-helper 1 Cell Cytokine Production
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Degradation of the extracellular matrix
Rho GTPase cycle
HDL assembly
Interleukin-1 processing
CLEC7A/inflammasome pathway
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling
Purinergic signaling in leishmaniasis infection
Drugs
Becaplermin
Cisplatin
Bacitracin
Zinc
Ocriplasmin
Silver
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Donepezil
Minocycline
VP025
Gallium nitrate
Talmapimod
Etiprednol dicloacetate
VX-702
VX-765
Andrographolide
Canakinumab
Rilonacept
Foreskin keratinocyte (neonatal)
Binimetinib
Gevokizumab
Dilmapimod
Diseases
GWAS
Refractive error (
32231278
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Birth weight (
31043758
)
Dysmenorrheic pain severity (
29855537
)
Gestational age at birth (child effect) (
31477735
)
Post-term birth (
31477735
)
Interacting Genes
96 interacting genes:
ACTB
ADAM19
ADAMTS1
AMBP
ANXA6
ANXA7
AP1M2
APOE
APP
ATF7IP
ATP1A1
B2M
C11orf58
CDC37
CDC42
CDK2AP2
CDKN1A
CELA1
CPB2
CTSB
CTSE
CYP2C18
CYP2C8
DNAJB1
ECSIT
EGLN2
ELAVL3
ENO2
EVI5L
EXOSC1
FARSA
FBXL12
FBXW4
FIS1
GCDH
GEM
GRB2
H2AX
HMOX2
HSPA5
HSPB2
IFIT3
IFIT5
IGSF8
IL10
IL1B
IL4
KLK1
KLK13
KLK2
KLK3
LCAT
LEP
LINC02582
LONP1
LRP1
LYZ
MAST1
MLST8
MMP2
MYOC
NCDN
NGF
NOS3
NUDT21
OGA
PAEP
PAXIP1
PDGFA
PDGFB
PRAM1
PRDX2
RAB3A
RAD23A
RAP1B
RETN
RHEB
RNF32
RPP14
SEPTIN8
SHBG
SMN1
STAMBPL1
SWSAP1
TGFBI
TGIF1
TGM2
TK1
TNFRSF14
TRAPPC5
TSC22D1
TTR
TUBA1B
TYRO3
UFD1
UMPS
15 interacting genes:
A2M
ADRB2
APP
CASP1
CASP4
CMA1
EGR1
FYN
IL1R1
IL1R2
IL1RAP
LYN
MMP2
PRTN3
SP1
Entrez ID
2
3553
HPRD ID
00072
00985
Ensembl ID
ENSG00000175899
ENSG00000125538
Uniprot IDs
P01023
P01584
PDB IDs
1BV8
2P9R
4ACQ
1HIB
1I1B
1IOB
1ITB
1L2H
1S0L
1T4Q
1TOO
1TP0
1TWE
1TWM
21BI
2I1B
2KH2
2NVH
31BI
3LTQ
3O4O
3POK
41BI
4DEP
4G6J
4G6M
4GAF
4GAI
4I1B
5BVP
5I1B
5MVZ
5R7W
5R85
5R86
5R87
5R88
5R89
5R8A
5R8B
5R8C
5R8D
5R8E
5R8F
5R8G
5R8H
5R8I
5R8J
5R8K
5R8L
5R8M
5R8N
5R8O
5R8P
5R8Q
6I1B
6Y8I
6Y8M
7I1B
9ILB
Enriched GO Terms of Interacting Partners
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