CELA1 and PI3

Data Source:
HPRD (in vivo)

		CELA1	PI3
Description		chymotrypsin like elastase 1	peptidase inhibitor 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Inflammatory Response Post-embryonic Development Wnt Signaling Pathway Exocrine Pancreas Development Multicellular Organism Growth Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Tissue Remodeling Elastin Catabolic Process Pancreas Morphogenesis	Copulation Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Antimicrobial Humoral Response Antibacterial Humoral Response Innate Immune Response Cornification
Pathways			Antimicrobial peptides Formation of the cornified envelope
Drugs		N,N-dimethylformamide Cumidine Mdl 101,146 2-[5-Methanesulfonylamino-2-(4-Aminophenyl)-6-Oxo-1,6-Dihydro-1-Pyrimidinyl]-N-(3,3,3-Trifluoro-1-Isopropyl-2-Oxopropyl)Acetamide N-{4-[(Carboxymethyl)carbamoyl]benzoyl}-L-valyl-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-3-pentanyl]-L-prolinamide N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-alanyl-L-alaninamide N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide Freselestat (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER METHYL(2-ACETOXY-2-(2-CARBOXY-4-AMINO-PHENYL))ACETATE (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID
Diseases
GWAS		Neutrophil count ( 32888494) Obesity-related traits ( 23251661)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488 28240269) Malaria ( 31844061)
Interacting Genes		6 interacting genes: A2M CSN2 LPA PI3 SERPINA1 SERPINA3	5 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN
Entrez ID		1990	5266
HPRD ID		00553	15947
Ensembl ID		ENSG00000139610	ENSG00000124102
Uniprot IDs		Q9UNI1	P19957
PDB IDs			1FLE 2REL 6ATU
Enriched GO Terms of Interacting Partners?
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