PI3 and EVPL

Data Source:
HPRD (in vivo)

		PI3	EVPL
Description		peptidase inhibitor 3	envoplakin
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix	Cornified Envelope Cytoplasm Cytosol Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis	Structural Molecule Activity Intermediate Filament Binding Cadherin Binding
	Biological Process	Copulation Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Antimicrobial Humoral Response Antibacterial Humoral Response Innate Immune Response Cornification	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways		Antimicrobial peptides Formation of the cornified envelope	Formation of the cornified envelope
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488 28240269) Malaria ( 31844061)	Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		5 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		5266	2125
HPRD ID		15947	03352
Ensembl ID		ENSG00000124102	ENSG00000167880
Uniprot IDs		P19957	B7ZLH8 K7EKI0 Q92817
PDB IDs		1FLE 2REL 6ATU	4QMD
Enriched GO Terms of Interacting Partners?
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