PI3 and KRT1

Data Source:
BioGRID (pull down)

		PI3	KRT1
Description		peptidase inhibitor 3	keratin 1
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Copulation Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Antimicrobial Humoral Response Antibacterial Humoral Response Innate Immune Response Cornification	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification
Pathways		Antimicrobial peptides Formation of the cornified envelope	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Copper Zinc acetate
Diseases			Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488 28240269) Malaria ( 31844061)
Interacting Genes		5 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN	51 interacting genes: AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 PI3 PRKCE RINT1 SGTB TFIP11 TLCD4 TRIM54 U2AF1 U2AF1L5 UBE3A YWHAQ
Entrez ID		5266	3848
HPRD ID		15947	00763
Ensembl ID		ENSG00000124102	ENSG00000167768
Uniprot IDs		P19957	P04264
PDB IDs		1FLE 2REL 6ATU	4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?
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