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DVL1 and TRIM69
Data Source:
BioGRID
(two hybrid)
DVL1
TRIM69
Description
dishevelled segment polarity protein 1
tripartite motif containing 69
Image
GO Annotations
Cellular Component
Cytosol
Microtubule
Postsynaptic Density
Lateral Plasma Membrane
Clathrin-coated Vesicle
Growth Cone
Cytoplasmic Vesicle
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Synapse
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Wnt Signalosome
Nucleus
Cytoplasm
Cytosol
Nuclear Speck
Molecular Function
Molecular_function
Frizzled Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Identical Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Regulation Of Neurotransmitter Levels
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Neurotransmitter Secretion
Axon Guidance
Heart Development
Neuromuscular Junction Development
Positive Regulation Of Neuron Projection Development
Neural Tube Development
Convergent Extension Involved In Neural Plate Elongation
Cytoplasmic Microtubule Organization
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Social Behavior
Protein Localization To Microtubule
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Receptor Clustering
Positive Regulation Of Transcription By RNA Polymerase II
Collateral Sprouting
Axon Extension
Dendrite Morphogenesis
Synapse Organization
Protein Stabilization
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Prepulse Inhibition
Dendritic Spine Morphogenesis
Skeletal Muscle Acetylcholine-gated Channel Clustering
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Presynapse Assembly
Positive Regulation Of Neuron Projection Arborization
Regulation Of Cellular Protein Localization
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Protein Localization To Presynapse
Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Excitatory Postsynaptic Potential
Protein Polyubiquitination
Apoptotic Process
Protein Ubiquitination
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
PCP/CE pathway
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Inflammatory bowel disease (
28067908
)
Nicotine dependence (
32281736
)
Ulcerative colitis (
28067908
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Interacting Genes
43 interacting genes:
ANXA7
ARRB1
ATN1
AXIN1
BAG3
BRD7
BUB1
CCDC88C
CSNK1D
CSNK1E
CSNK2A1
CTNNB1
CXXC4
DAAM1
DAB2
DVL3
DYNLT1
EPS8
FBXW7
FRAT1
HDHD2
HECW1
KLHL12
LRRK2
MLH3
MSH2
NCK2
NEDD4
PPM1A
PSMA3
RAC1
RB1
SIPA1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
SMYD1
TRIM69
USP13
VANGL1
VANGL2
53 interacting genes:
AIFM2
APP
ASNS
ATP5MC1
BEX2
BIN3
C4orf45
CDSN
DVL1
ETFDH
FAM110A
FAM161A
FAM90A1
FKBP1B
GEM
HAUS1
HGS
IYD
KLHL38
KRT17
LARP1B
LYSMD1
MAGEA4
MAJIN
MED20
MID2
NEK8
NTAQ1
PML
POLR3K
PPP1R18
RECK
RINT1
RSPH14
SF1
SF3A3
SKIL
STMN3
SYCE2
SYNE4
TNNT2
TRIM44
TRIM54
TRIM55
TRIM63
UBE2D1
UBE2D3
UBE2E1
UBE2H
UBE2N
WASHC1
WWOX
ZNF483
Entrez ID
1855
140691
HPRD ID
03220
11518
Ensembl ID
ENSG00000107404
ENSG00000185880
Uniprot IDs
O14640
H0YL66
Q86WT6
PDB IDs
6TTK
4NQJ
6YXE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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