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DYNC1I2 and DCTN1
Data Source:
BioGRID
(proximity labelling technology)
HPRD
(in vitro)
DYNC1I2
DCTN1
Description
dynein cytoplasmic 1 intermediate chain 2
dynactin subunit 1
Image
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Cytosol
Cytoplasmic Dynein Complex
Microtubule
Vesicle
Kinetochore
Spindle Pole
Nucleus
Nuclear Envelope
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Microtubule
Microtubule Associated Complex
Cell Cortex
Microtubule Cytoskeleton
Membrane
Dynein Complex
Axon
Retromer Complex
Microtubule Plus-end
Neuron Projection
Neuronal Cell Body
Intercellular Bridge
Mitotic Spindle
Cell Cortex Region
Centriolar Subdistal Appendage
Molecular Function
Microtubule Motor Activity
Protein Binding
Dynein Light Chain Binding
Dynein Heavy Chain Binding
Motor Activity
Protein Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Tau Protein Binding
Microtubule Plus-end Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Microtubule-based Movement
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Transport Along Microtubule
Viral Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Ciliary Basal Body-plasma Membrane Docking
G2/M Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Nuclear Migration
Nervous System Development
Neuromuscular Junction Development
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Centriole-centriole Cohesion
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Ventral Spinal Cord Development
Positive Regulation Of Microtubule Polymerization
Cytoplasmic Microtubule Organization
Microtubule Anchoring At Centrosome
IRE1-mediated Unfolded Protein Response
Retrograde Transport, Endosome To Golgi
Neuromuscular Process
Nuclear Envelope Disassembly
Cell Division
Regulation Of Mitotic Spindle Organization
Motor Behavior
Neuron Cellular Homeostasis
Positive Regulation Of Microtubule Nucleation
Ciliary Basal Body-plasma Membrane Docking
Axonal Transport
Maintenance Of Synapse Structure
Positive Regulation Of Neuromuscular Junction Development
Non-motile Cilium Assembly
Neuron Projection Maintenance
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2
HCMV Early Events
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
XBP1(S) activates chaperone genes
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Perry syndrome
Distal hereditary motor neuropathies (dHMN)
GWAS
Hippocampal volume (
25625606
)
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Weight (
28552196
)
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Refractive error (
32231278
)
Interacting Genes
8 interacting genes:
CCDC136
DCTN1
DYNLRB1
DYNLT1
DYNLT3
NECAB2
PNN
PPFIA1
46 interacting genes:
ACTR1A
ACTR1B
AKT1
APEX1
BBS1
BBS4
BICD1
BICD2
CASP2
CASP3
CASP7
CDC37
CLIP1
DCTN3
DISC1
DST
DTNBP1
DYNC1I2
ENO3
FBXL5
GRB2
GSK3B
HAP1
HSPB2
KIAA0408
KIF11
MAP2K3
MAP2K6
MAPRE1
MED14
MTERF1
NEK2
NOD2
PAFAH1B1
PFDN1
PGAM1
PPP1CA
RAB6A
RBL2
RPGR
SEC23A
SPTBN2
STAT1
TP53RK
VIM
ZNF512B
Entrez ID
1781
1639
HPRD ID
04512
07206
Ensembl ID
ENSG00000077380
ENSG00000204843
Uniprot IDs
A0A140VKE9
B4DPZ3
Q13409
Q14203
Q6MZZ3
PDB IDs
5JPW
6F1T
6F1U
6F1Z
6F38
6F3A
1TXQ
2COY
2HKN
2HKQ
2HL3
2HL5
2HQH
3E2U
3TQ7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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