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DCTN1 and RPGR
Data Source:
HPRD
(in vivo)
DCTN1
RPGR
Description
dynactin subunit 1
retinitis pigmentosa GTPase regulator
Image
GO Annotations
Cellular Component
Kinetochore
Spindle Pole
Nucleus
Nuclear Envelope
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Microtubule
Microtubule Associated Complex
Cell Cortex
Microtubule Cytoskeleton
Membrane
Dynein Complex
Axon
Retromer Complex
Microtubule Plus-end
Neuron Projection
Neuronal Cell Body
Intercellular Bridge
Mitotic Spindle
Cell Cortex Region
Centriolar Subdistal Appendage
Photoreceptor Outer Segment
Golgi Apparatus
Centrosome
Ciliary Basal Body
Sperm Flagellum
Molecular Function
Motor Activity
Protein Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Tau Protein Binding
Microtubule Plus-end Binding
RNA Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Nuclear Migration
Nervous System Development
Neuromuscular Junction Development
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Centriole-centriole Cohesion
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Ventral Spinal Cord Development
Positive Regulation Of Microtubule Polymerization
Cytoplasmic Microtubule Organization
Microtubule Anchoring At Centrosome
IRE1-mediated Unfolded Protein Response
Retrograde Transport, Endosome To Golgi
Neuromuscular Process
Nuclear Envelope Disassembly
Cell Division
Regulation Of Mitotic Spindle Organization
Motor Behavior
Neuron Cellular Homeostasis
Positive Regulation Of Microtubule Nucleation
Ciliary Basal Body-plasma Membrane Docking
Axonal Transport
Maintenance Of Synapse Structure
Positive Regulation Of Neuromuscular Junction Development
Non-motile Cilium Assembly
Neuron Projection Maintenance
Intracellular Protein Transport
Visual Perception
Intraciliary Transport
Regulation Of Catalytic Activity
Response To Stimulus
Cilium Assembly
Pathways
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
XBP1(S) activates chaperone genes
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Perry syndrome
Distal hereditary motor neuropathies (dHMN)
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
Retinitis pigmentosa (RP)
GWAS
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Refractive error (
32231278
)
Interacting Genes
46 interacting genes:
ACTR1A
ACTR1B
AKT1
APEX1
BBS1
BBS4
BICD1
BICD2
CASP2
CASP3
CASP7
CDC37
CLIP1
DCTN3
DISC1
DST
DTNBP1
DYNC1I2
ENO3
FBXL5
GRB2
GSK3B
HAP1
HSPB2
KIAA0408
KIF11
MAP2K3
MAP2K6
MAPRE1
MED14
MTERF1
NEK2
NOD2
PAFAH1B1
PFDN1
PGAM1
PPP1CA
RAB6A
RBL2
RPGR
SEC23A
SPTBN2
STAT1
TP53RK
VIM
ZNF512B
14 interacting genes:
DCTN1
DCTN2
HOMEZ
IFT88
KIF3A
KIFAP3
NPM1
PDE6D
RPGRIP1
SLC25A10
SMC1A
SMC3
TUBG1
YWHAE
Entrez ID
1639
6103
HPRD ID
07206
02425
Ensembl ID
ENSG00000204843
ENSG00000156313
Uniprot IDs
Q14203
Q6MZZ3
Q92834
PDB IDs
1TXQ
2COY
2HKN
2HKQ
2HL3
2HL5
2HQH
3E2U
3TQ7
4JHN
4JHP
4QAM
Enriched GO Terms of Interacting Partners
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