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DYNC1I2 and DYNLT1
Data Source:
BioGRID
(proximity labelling technology, two hybrid)
DYNC1I2
DYNLT1
Description
dynein cytoplasmic 1 intermediate chain 2
dynein light chain Tctex-type 1
Image
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Cytosol
Cytoplasmic Dynein Complex
Microtubule
Vesicle
Extracellular Region
Mitochondrion
Golgi Apparatus
Spindle
Cytoplasmic Dynein Complex
Cytoplasmic Microtubule
Lamellipodium
Secretory Granule Lumen
Neuronal Cell Body
Host Cell
Axonal Growth Cone
Secretory Vesicle
Ficolin-1-rich Granule Lumen
Molecular Function
Microtubule Motor Activity
Protein Binding
Dynein Light Chain Binding
Dynein Heavy Chain Binding
Motor Activity
Protein Binding
Protein C-terminus Binding
Identical Protein Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Microtubule-based Movement
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Transport Along Microtubule
Viral Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Ciliary Basal Body-plasma Membrane Docking
Establishment Of Mitotic Spindle Orientation
Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Neuron Projection Development
Dendrite Development
Intracellular Transport Of Viral Protein In Host Cell
Positive Regulation Of Rac Protein Signal Transduction
Negative Regulation Of Mitochondrial Membrane Permeability
Regulation Of GTPase Activity
Neutrophil Degranulation
Viral Entry Into Host Cell
Neuron Projection Morphogenesis
Negative Regulation Of Neurogenesis
Cell Division
Regulation Of Cytoskeleton Organization
Negative Regulation Of Cell Death
Axon Development
Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2
HCMV Early Events
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Neutrophil degranulation
Drugs
Diseases
GWAS
Hippocampal volume (
25625606
)
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Weight (
28552196
)
Interacting Genes
8 interacting genes:
CCDC136
DCTN1
DYNLRB1
DYNLT1
DYNLT3
NECAB2
PNN
PPFIA1
50 interacting genes:
ACOX2
ACTN1
APP
ARID4B
BAG3
BMPR2
CCDC68
DDX54
DHX33
DNAJA2
DOC2A
DOC2B
DVL1
DVL2
DYNC1I1
DYNC1I2
DYNLT2B
DYNLT3
FXR2
HAVCR1
HSPB7
HSPB9
ILF2
KIF2A
KLK15
LNX1
NHSL2
NTAQ1
NUP153
NUP62
OLFM3
PELO
PITX2
PSMA1
PTGES3L-AARSD1
PTH2R
PVR
RAD21
RBM14
RRAGA
SDCBP
SIRPA
SVIL
TCEANC
TROAP
TUBA3C
TXN
UXT
VDAC1
XRN2
Entrez ID
1781
6993
HPRD ID
04512
15987
Ensembl ID
ENSG00000077380
ENSG00000146425
Uniprot IDs
A0A140VKE9
B4DPZ3
Q13409
P63172
PDB IDs
5JPW
6F1T
6F1U
6F1Z
6F38
6F3A
5JPW
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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