DAXX and HIPK1

Data Source:
HPRD (in vivo, in vitro)

		DAXX	HIPK1
Description		death domain associated protein	homeodomain interacting protein kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body PML Body	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol PML Body Nuclear Speck
	Molecular Function	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein N-terminus Binding Androgen Receptor Binding Sumo-dependent Protein Binding Transcription Regulator Inhibitor Activity	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Activation Of JUN Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Heat Cellular Response To Unfolded Protein Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Positive Regulation Of Neuron Death Cellular Response To Sodium Arsenite	Eye Development Protein Phosphorylation Smoothened Signaling Pathway Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Neuron Differentiation Adherens Junction Assembly Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Angiogenesis Embryonic Camera-type Eye Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Definitive Hemopoiesis Lens Induction In Camera-type Eye Iris Morphogenesis Endothelial Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator
Pathways		SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Alopecia areata ( 25608926) Breast cancer ( 23535729) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Heel bone mineral density ( 30598549)
Interacting Genes		113 interacting genes: ACVR2A AIRE AMOTL2 AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CEP63 CEP70 CFLAR CREBBP CSNK2A1 DAPK3 DKC1 DMAP1 DNMT1 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GAS8 GOLGA2 GOLGA6L9 GRIPAP1 H3-3A H3-3B H3-5 H3C3 H4-16 H4C6 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 KCTD4 MAP3K5 MCRS1 MDM2 MEN1 MIPOL1 MKRN1 MSANTD4 MX1 MYH11 NECAB2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PIBF1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RASSF3 RIPK3 RNF4 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SQSTM1 SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TAX1BP1 TCF3 TCF4 TCF7L2 TFIP11 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TRIM54 TSG101 UBC UBE2I USH1G USP7 ZBTB2 ZBTB26	14 interacting genes: ATP13A2 CREBBP DAXX FHL3 GLUL HOXD4 NKX2-5 PARK7 PRPF40A RUNX1 SKIL SNIP1 TP53 UBE2I
Entrez ID		1616	204851
HPRD ID		04424	06418
Ensembl ID		ENSG00000204209	ENSG00000163349
Uniprot IDs		A0A024RCS3 B4E1C1 Q53F85 Q9UER7	A0A024R0H9 B4DZ33 Q86Z02
PDB IDs		2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O
Enriched GO Terms of Interacting Partners?
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