HIPK1 and NKX2-5

Data Source:
HPRD (in vitro, two hybrid)

		HIPK1	NKX2-5
Description		homeodomain interacting protein kinase 1	NK2 homeobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol PML Body Nuclear Speck	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Eye Development Protein Phosphorylation Smoothened Signaling Pathway Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Neuron Differentiation Adherens Junction Assembly Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Angiogenesis Embryonic Camera-type Eye Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Definitive Hemopoiesis Lens Induction In Camera-type Eye Iris Morphogenesis Endothelial Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Tissue Development Septum Secundum Development Regulation Of Transcription By RNA Polymerase II Adult Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Regulation of TP53 Activity through Phosphorylation	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors
Drugs
Diseases			Atrial septal defect Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Alopecia areata ( 25608926) Breast cancer ( 23535729) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Heel bone mineral density ( 30598549)	Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) Ischemic stroke (cardioembolic) ( 29531354) PR interval ( 30046033 32439900 20062060) Resting heart rate ( 27798624) Stroke ( 26089329) TPE interval (resting) ( 32386560)
Interacting Genes		14 interacting genes: ATP13A2 CREBBP DAXX FHL3 GLUL HOXD4 NKX2-5 PARK7 PRPF40A RUNX1 SKIL SNIP1 TP53 UBE2I	18 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10
Entrez ID		204851	1482
HPRD ID		06418	02787
Ensembl ID		ENSG00000163349	ENSG00000183072
Uniprot IDs		A0A024R0H9 B4DZ33 Q86Z02	A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952
PDB IDs			3RKQ 4S0H 6WC2 6WC5
Enriched GO Terms of Interacting Partners?
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