HIPK1 and HOXD4

Data Source:
HPRD (in vitro, two hybrid)

		HIPK1	HOXD4
Description		homeodomain interacting protein kinase 1	homeobox D4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol PML Body Nuclear Speck	Chromatin Nucleus Nucleoplasm Cell Junction
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Eye Development Protein Phosphorylation Smoothened Signaling Pathway Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Neuron Differentiation Adherens Junction Assembly Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Angiogenesis Embryonic Camera-type Eye Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Definitive Hemopoiesis Lens Induction In Camera-type Eye Iris Morphogenesis Endothelial Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Regulation of TP53 Activity through Phosphorylation	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Breast cancer ( 23535729) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Heel bone mineral density ( 30598549)	Estimated glomerular filtration rate ( 31015462) Male-pattern baldness ( 28196072) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		14 interacting genes: ATP13A2 CREBBP DAXX FHL3 GLUL HOXD4 NKX2-5 PARK7 PRPF40A RUNX1 SKIL SNIP1 TP53 UBE2I	21 interacting genes: ASB8 CNOT7 CREBBP DEDD EP300 ETV4 FANCL HIPK1 HNRNPAB HOXB13 MEIS1 PBX1 PBX4 RNPS1 RXRG SNAI1 TIGD4 XRCC6 ZBTB32 ZMYND11 ZSCAN18
Entrez ID		204851	3233
HPRD ID		06418	00864
Ensembl ID		ENSG00000163349	ENSG00000170166
Uniprot IDs		A0A024R0H9 B4DZ33 Q86Z02	P09016
PDB IDs
Enriched GO Terms of Interacting Partners?
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