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CSNK1A1 and RCC1
Data Source:
HPRD
(in vitro, in vivo)
CSNK1A1
RCC1
Description
casein kinase 1 alpha 1
regulator of chromosome condensation 1
Image
GO Annotations
Cellular Component
Condensed Chromosome Kinetochore
Nucleus
Cytoplasm
Centrosome
Cytosol
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Cilium
Membrane
Nuclear Speck
Beta-catenin Destruction Complex
Ciliary Basal Body
Keratin Filament
Chromatin
Condensed Nuclear Chromosome
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Membrane
Protein-containing Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Chromatin Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Small GTPase Binding
Nucleosome Binding
Nucleosomal DNA Binding
Histone Binding
Sulfate Binding
Protein Heterodimerization Activity
Biological Process
Protein Phosphorylation
Golgi Organization
Cell Cycle
Signal Transduction
Cell Surface Receptor Signaling Pathway
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Cell Division
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of GTP Binding
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
G1/S Transition Of Mitotic Cell Cycle
Mitotic Spindle Organization
Chromosome Segregation
Regulation Of Mitotic Nuclear Division
Viral Process
Ran Protein Signal Transduction
Regulation Of Catalytic Activity
Spindle Assembly
Cell Division
Regulation Of Mitotic Spindle Assembly
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Activation of SMO
Activation of SMO
Rev-mediated nuclear export of HIV RNA
Nuclear import of Rev protein
Postmitotic nuclear pore complex (NPC) reformation
Drugs
Fostamatinib
Diseases
GWAS
Carotid intima media thickness x smoking interaction (
32117412
)
Chronic obstructive pulmonary disease (
30804561
)
Esophageal cancer (
21642993
)
Night sleep phenotypes (
27126917
)
Systolic blood pressure (
30578418
)
Interacting Genes
48 interacting genes:
ACTB
ADAP1
AP3B1
AP3B2
APC
AXIN1
BID
CDC25A
CHRM3
CRBN
CREM
CTNNB1
EIF2B5
ERF
FADD
GLI3
GNB2
HMGB1
HMGB2
HNRNPC
HSPA4
KPNA2
KPNB1
LGALS3
MAPT
MDM4
NFATC3
OCLN
PDE4D
PHLPP1
PPP1CC
PPP1R14A
PPP2R5A
PSEN2
PTEN
RCC1
SLC18A2
SNCA
SQSTM1
SYT9
TGFBR1
TIAM1
TNFRSF1B
TP53
UVRAG
YWHAQ
YWHAZ
ZRANB1
50 interacting genes:
ACTB
APLP1
BAG6
CCT7
CDK1
CDK2AP2
CHGB
CHKA
CSAD
CSNK1A1
DDAH2
DYNC1I1
ERCC6
FAF1
FBXO7
FLAD1
GNB2
H2AC18
H2AC20
H2BC21
H3C1
HADHB
HMGA1
HOXD8
KMT2B
KPNA3
KPNA4
LRIF1
NGFR
NTMT1
NUDT21
NUP98
PDHB
PKM
PTMA
RAN
RANBP1
RANBP3
RPA1
SDF4
SPRED1
SUMO2
TLE1
TRMT2A
TUBB3
UNC119
USP4
WIZ
XPO1
ZNF135
Entrez ID
1452
1104
HPRD ID
02739
01559
Ensembl ID
ENSG00000113712
ENSG00000180198
Uniprot IDs
B4DER9
P48729
Q6PJ06
A0A0S2Z3I4
A0A0S2Z404
P18754
Q5T081
PDB IDs
5FQD
6GZD
1A12
1I2M
5E1B
5E1D
5E1M
5E1O
5E2A
5E2B
5TBK
6DUB
Enriched GO Terms of Interacting Partners
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