Wiki-Pi
About
Search
Browse
People
Updates
Search
CSNK1A1 and FADD
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, in vitro)
CSNK1A1
FADD
Description
casein kinase 1 alpha 1
Fas associated via death domain
Image
GO Annotations
Cellular Component
Condensed Chromosome Kinetochore
Nucleus
Cytoplasm
Centrosome
Cytosol
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Cilium
Membrane
Nuclear Speck
Beta-catenin Destruction Complex
Ciliary Basal Body
Keratin Filament
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Neuron Projection
Cell Body
Membrane Raft
Ripoptosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protease Binding
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Tumor Necrosis Factor Receptor Superfamily Binding
Receptor Serine/threonine Kinase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Caspase Binding
Biological Process
Protein Phosphorylation
Golgi Organization
Cell Cycle
Signal Transduction
Cell Surface Receptor Signaling Pathway
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Cell Division
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of GTP Binding
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Kidney Development
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Adaptive Immune Response
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Surface Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Viral Process
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
T Cell Differentiation In Thymus
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Morphine
Innate Immune Response
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Cocaine
Lymph Node Development
Spleen Development
Thymus Development
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Necroptotic Process
Negative Regulation Of Activation-induced Cell Death Of T Cells
Cellular Response To Mechanical Stimulus
Death-inducing Signaling Complex Assembly
Motor Neuron Apoptotic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of Cysteine-type Endopeptidase Activity
Necroptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Activation of SMO
Activation of SMO
Caspase activation via Death Receptors in the presence of ligand
TRIF-mediated programmed cell death
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Defective RIPK1-mediated regulated necrosis
Drugs
Fostamatinib
Diseases
GWAS
Carotid intima media thickness x smoking interaction (
32117412
)
Chronic obstructive pulmonary disease (
30804561
)
Esophageal cancer (
21642993
)
Diverticular disease (
30177863
)
Interacting Genes
48 interacting genes:
ACTB
ADAP1
AP3B1
AP3B2
APC
AXIN1
BID
CDC25A
CHRM3
CRBN
CREM
CTNNB1
EIF2B5
ERF
FADD
GLI3
GNB2
HMGB1
HMGB2
HNRNPC
HSPA4
KPNA2
KPNB1
LGALS3
MAPT
MDM4
NFATC3
OCLN
PDE4D
PHLPP1
PPP1CC
PPP1R14A
PPP2R5A
PSEN2
PTEN
RCC1
SLC18A2
SNCA
SQSTM1
SYT9
TGFBR1
TIAM1
TNFRSF1B
TP53
UVRAG
YWHAQ
YWHAZ
ZRANB1
54 interacting genes:
ABCA1
ANK3
ATG5
BTG1
CASP10
CASP8
CASP8AP2
CFLAR
CSNK1A1
DAP3
DAPK1
DDIT4L
DDX24
DEDD
EDA2R
FAF1
FAS
FASLG
HIPK3
IKBKG
IRAK1
LRRCC1
MBD4
MKRN1
MOB4
MYD88
NACA
NOL3
NUTM2F
PARK7
PEA15
PIDD1
PIN1
PRKCZ
PTPN13
RALBP1
RAP1A
RIPK1
RNF4
RYBP
SDCBP
STAT1
STUB1
TAB1
TCEA2
TNFRSF10A
TNFRSF10B
TRADD
TRAF2
TRIM21
UBE2I
XPO5
ZCCHC12
ZMYM5
Entrez ID
1452
8772
HPRD ID
02739
03909
Ensembl ID
ENSG00000113712
ENSG00000168040
Uniprot IDs
B4DER9
P48729
Q6PJ06
Q13158
PDB IDs
5FQD
6GZD
1A1W
1A1Z
1E3Y
1E41
2GF5
3EZQ
3OQ9
6ACI
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?