HUS1B and RAD1

Data Source:
HPRD (in vivo, two hybrid)

		HUS1B	RAD1
Description		HUS1 checkpoint clamp component B	RAD1 checkpoint DNA exonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Checkpoint Clamp Complex Site Of Double-strand Break	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex Intracellular Membrane-bounded Organelle
	Molecular Function		Damaged DNA Binding Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Meiotic DNA Integrity Checkpoint	DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Substantia Nigra Development Meiotic Recombination Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Aging ( 22773346) Metabolite levels ( 23823483)	Daytime sleep phenotypes ( 27126917)
Interacting Genes		4 interacting genes: HUS1 RAD1 RAD9A RAD9B	24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN
Entrez ID		135458	5810
HPRD ID		13722	04400
Ensembl ID		ENSG00000188996	ENSG00000113456
Uniprot IDs		Q8NHY5	A0A024R045 O60671
PDB IDs			3A1J 3G65 3GGR 6J8Y
Enriched GO Terms of Interacting Partners?
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