HUS1B and RAD9A

Data Source:
HPRD (in vivo)

		HUS1B	RAD9A
Description		HUS1 checkpoint clamp component B	RAD9 checkpoint clamp component A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Checkpoint Clamp Complex Site Of Double-strand Break	Nucleus Nucleoplasm Checkpoint Clamp Complex
	Molecular Function		Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Meiotic DNA Integrity Checkpoint	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Aging ( 22773346) Metabolite levels ( 23823483)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		4 interacting genes: HUS1 RAD1 RAD9A RAD9B	38 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN
Entrez ID		135458	5883
HPRD ID		13722	04788
Ensembl ID		ENSG00000188996	ENSG00000172613
Uniprot IDs		Q8NHY5	Q99638
PDB IDs			3A1J 3G65 3GGR 6HM5 6J8Y
Enriched GO Terms of Interacting Partners?
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