RAD1 and NEIL1

Data Source:
BioGRID (pull down)

		RAD1	NEIL1
Description		RAD1 checkpoint DNA exonuclease	nei like DNA glycosylase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center
	Molecular Function	Damaged DNA Binding Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein C-terminus Binding Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Substantia Nigra Development Meiotic Recombination Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator	Base-excision Repair Response To Oxidative Stress Negative Regulation Of Nuclease Activity Depyrimidination
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective Base Excision Repair Associated with NEIL1
Drugs			Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)
Interacting Genes		24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN	6 interacting genes: APP HUS1 LIG3 POLB RAD1 XRCC1
Entrez ID		5810	79661
HPRD ID		04400	12314
Ensembl ID		ENSG00000113456	ENSG00000140398
Uniprot IDs		A0A024R045 O60671	Q96FI4
PDB IDs		3A1J 3G65 3GGR 6J8Y	1TDH 4NRV 5ITQ 5ITR 5ITT 5ITU 5ITX 5ITY
Enriched GO Terms of Interacting Partners?
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