ADM and MME

Data Source:
HPRD (in vitro)

		ADM	MME
Description		adrenomedullin	membrane metalloendopeptidase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Cytoplasm Early Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Integral Component Of Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse
	Molecular Function	Signaling Receptor Binding Hormone Activity Adrenomedullin Receptor Binding	Phosphatidylserine Binding Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Peptide Binding Protein Homodimerization Activity Oligopeptidase Activity Cardiolipin Binding
	Biological Process	Vasculogenesis Response To Hypoxia Neural Tube Closure Regulation Of The Force Of Heart Contraction G Protein-coupled Receptor Internalization Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Aging Androgen Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Cold Response To Wounding Positive Regulation Of Heart Rate Animal Organ Regeneration Neuron Projection Regeneration Receptor Internalization Response To Lipopolysaccharide Response To Insulin Regulation Of Urine Volume Odontogenesis Of Dentin-containing Tooth Response To Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Hormone Secretion Developmental Growth Response To Glucocorticoid Branching Involved In Labyrinthine Layer Morphogenesis Vascular Associated Smooth Muscle Cell Development Amylin Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Positive Regulation Of Progesterone Biosynthetic Process Positive Regulation Of Vasculogenesis	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Aging Learning Or Memory Protein Processing Sensory Perception Of Pain Lung Development Neutrophil Degranulation Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation
Drugs			Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat
Diseases
GWAS		Birth weight ( 31043758) Blood pressure ( 21909110) Blood protein levels in cardiovascular risk ( 28369058) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 27841878 21909115 27618452) HDL cholesterol ( 20686565) Neuroticism ( 27089181) Pulse pressure ( 27841878) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 27841878 21909115 27618452)	Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878)
Interacting Genes		4 interacting genes: CALCRL CFH EDN1 MME	18 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 VIP
Entrez ID		133	4311
HPRD ID		00061	00392
Ensembl ID		ENSG00000148926	ENSG00000196549
Uniprot IDs		P35318	P08473
PDB IDs		2FLY 2L7S 4RWF 5V6Y 6UUN 6UUS 6V2E	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP
Enriched GO Terms of Interacting Partners?
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