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CCDC43 and PNKP
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
CCDC43
PNKP
Description
coiled-coil domain containing 43
polynucleotide kinase 3'-phosphatase
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Nucleus
Nucleoplasm
Nucleolus
Mitochondrion
Membrane
Molecular Function
Protein Binding
Damaged DNA Binding
Double-stranded DNA Binding
Endonuclease Activity
Protein Binding
ATP Binding
Purine Nucleotide Binding
Polynucleotide 3'-phosphatase Activity
ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
Biological Process
Nucleotide-excision Repair, DNA Damage Removal
DNA-dependent DNA Replication
DNA Repair
Response To Oxidative Stress
Response To Radiation
Negative Regulation Of Protein ADP-ribosylation
Dephosphorylation
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Damage Response, Detection Of DNA Damage
Nucleotide Phosphorylation
Positive Regulation Of Telomerase Activity
Nucleic Acid Phosphodiester Bond Hydrolysis
Polynucleotide 3' Dephosphorylation
Positive Regulation Of Telomere Capping
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases
Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS
Interacting Genes
5 interacting genes:
KLHL2
LRRK2
MFHAS1
PNKP
TINF2
49 interacting genes:
APP
CACFD1
CAMK2B
CARD10
CCDC14
CCDC43
CISD2
CNTROB
COL17A1
DVL3
FADS6
GAS8
GZMK
IKZF1
KANK2
KDM1A
KLHL12
KRTAP4-12
LMNA
MAGEA11
MCC
MEOX2
MGST2
MSANTD4
MYOZ1
OBI1
PICK1
PNMA5
POLB
PSTPIP1
RPRM
SFT2D1
SMAD5
SNX2
SP4
SUV39H1
SYNGR1
SYNGR3
SYP
TARBP2
TBC1D1
THAP1
TMEM239
TNIP1
TRIM37
XRCC1
XRCC4
ZBTB14
ZNF639
Entrez ID
124808
11284
HPRD ID
08107
09284
Ensembl ID
ENSG00000180329
ENSG00000039650
Uniprot IDs
Q96MW1
Q96T60
PDB IDs
2BRF
2W3O
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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