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PNKP and COL17A1
Data Source:
BioGRID
(two hybrid)
PNKP
COL17A1
Description
polynucleotide kinase 3'-phosphatase
collagen type XVII alpha 1 chain
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Mitochondrion
Membrane
Extracellular Region
Collagen Trimer
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Hemidesmosome
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Damaged DNA Binding
Double-stranded DNA Binding
Endonuclease Activity
Protein Binding
ATP Binding
Purine Nucleotide Binding
Polynucleotide 3'-phosphatase Activity
ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Biological Process
Nucleotide-excision Repair, DNA Damage Removal
DNA-dependent DNA Replication
DNA Repair
Response To Oxidative Stress
Response To Radiation
Negative Regulation Of Protein ADP-ribosylation
Dephosphorylation
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Damage Response, Detection Of DNA Damage
Nucleotide Phosphorylation
Positive Regulation Of Telomerase Activity
Nucleic Acid Phosphodiester Bond Hydrolysis
Polynucleotide 3' Dephosphorylation
Positive Regulation Of Telomere Capping
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Cell-matrix Adhesion
Epidermis Development
Extracellular Matrix Organization
Hemidesmosome Assembly
Regulation Of Immune Response
Pathways
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Collagen degradation
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Type I hemidesmosome assembly
Collagen chain trimerization
Drugs
Diseases
Early infantile epileptic encephalopathy; Ohtahara syndrome
Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS
Cardiac hypertrophy (
21348951
)
Interacting Genes
49 interacting genes:
APP
CACFD1
CAMK2B
CARD10
CCDC14
CCDC43
CISD2
CNTROB
COL17A1
DVL3
FADS6
GAS8
GZMK
IKZF1
KANK2
KDM1A
KLHL12
KRTAP4-12
LMNA
MAGEA11
MCC
MEOX2
MGST2
MSANTD4
MYOZ1
OBI1
PICK1
PNMA5
POLB
PSTPIP1
RPRM
SFT2D1
SMAD5
SNX2
SP4
SUV39H1
SYNGR1
SYNGR3
SYP
TARBP2
TBC1D1
THAP1
TMEM239
TNIP1
TRIM37
XRCC1
XRCC4
ZBTB14
ZNF639
18 interacting genes:
ACTN1
ACTN4
CLSTN1
CSTF2T
CTNND1
DSP
DST
ITGA6
ITGB4
KRT18
LAD1
PLEC
PLOD3
PNKP
PPIL1
PPL
UBQLN2
WHRN
Entrez ID
11284
1308
HPRD ID
09284
00223
Ensembl ID
ENSG00000039650
ENSG00000065618
Uniprot IDs
Q96T60
Q9UMD9
PDB IDs
2BRF
2W3O
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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