PNKP and CNTROB

Data Source:
BioGRID (two hybrid)

		PNKP	CNTROB
Description		polynucleotide kinase 3'-phosphatase	centrobin, centriole duplication and spindle assembly protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane	Centrosome Centriole Cytosol
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	Protein Binding Protein Domain Specific Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Centriole Replication Centrosome Separation Regulation Of Cilium Assembly Mitotic Cytokinetic Process
Pathways		APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Refractive error ( 32231278)
Interacting Genes		49 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CCDC43 CISD2 CNTROB COL17A1 DVL3 FADS6 GAS8 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	17 interacting genes: APTX COASY CWF19L2 DAPK1 DUSP29 ELOA EPM2AIP1 LYST MCRS1 PELI1 PNKP RAD23A RSPH14 SYT6 TCEA2 TSHZ2 TTC23
Entrez ID		11284	116840
HPRD ID		09284	13991
Ensembl ID		ENSG00000039650	ENSG00000170037
Uniprot IDs		Q96T60	Q8N137
PDB IDs		2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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