FRA10AC1 and PRPF3

Data Source:
BioGRID (two hybrid)

		FRA10AC1	PRPF3
Description		FRA10A associated CGG repeat 1	pre-mRNA processing factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome
	Molecular Function	Protein Binding Phosphatase Activity	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Dephosphorylation	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 26252872 29274321) Refractive error ( 32231278)	Ambidextrousness ( 32989287) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Low density lipoprotein cholesterol levels ( 30498476) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ADPRS C7orf25 CHERP CWC27 EEF1D ESS2 GATD3A GDPD2 GLRX3 HABP4 IK KASH5 MAP3K12 MFAP1 MOB2 NKAP PLPPR4 PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830	52 interacting genes: BRCA1 CARD10 CASK CCDC125 CCDC136 CCDC85B CDC5L CEP70 CTNNBL1 DPY30 DVL2 DVL3 FAM9B FCHO1 FRA10AC1 GOLGA2 GPRASP2 GTPBP3 HSF2BP LZTS1 MAPRE1 MID2 NACC1 NAV2 NINL NKAP NKAPD1 OSBPL3 PCBP1 PHC2 PIP4K2B PRPF31 PSMD3 RABEP1 RBM39 RNF151 SART3 SHKBP1 SNIP1 SNRNP200 SSX2IP TRIM39 TSPYL1 TXLNA U2AF2 USP4 WBP4 ZBTB8A ZCCHC10 ZFPM2 ZGPAT ZRANB1
Entrez ID		118924	9129
HPRD ID		12319	07389
Ensembl ID		ENSG00000148690	ENSG00000117360
Uniprot IDs		Q70Z53	O43395
PDB IDs			1X4Q 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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