CHRNG and CHRNA1

Data Source:
HPRD (in vitro)

		CHRNG	CHRNA1
Description		cholinergic receptor nicotinic gamma subunit	cholinergic receptor nicotinic alpha 1 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Synapse Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity	Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential	Skeletal Muscle Contraction Cation Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Ion Transmembrane Transport Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Nervous System Process Musculoskeletal Movement Neuromuscular Process Excitatory Postsynaptic Potential Neuron Cellular Homeostasis
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs			Lamotrigine Agmatine
Diseases		Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)	Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
GWAS		Refractive error ( 23396134 32231278)	Atrial fibrillation ( 29892015)
Interacting Genes		21 interacting genes: ADAMTSL4 CHRNA1 CYSRT1 KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP5-9 KRTAP9-3 MDFI MEOX2 NBPF19 NOTCH2NLA SGTA SNX1 SPRY2	5 interacting genes: CHRND CHRNE CHRNG ITGA7 LILRB3
Entrez ID		1146	1134
HPRD ID		00009	00007
Ensembl ID		ENSG00000196811	ENSG00000138435
Uniprot IDs		A0A6F7YAP6 P07510	P02708 Q53SH4
PDB IDs			1Y5P 1Y5T 1Y6C 4ZJS 5HBT
Enriched GO Terms of Interacting Partners?
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