CHRNA1 and CHRND

Data Source:
HPRD (in vitro)

		CHRNA1	CHRND
Description		cholinergic receptor nicotinic alpha 1 subunit	cholinergic receptor nicotinic delta subunit
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane	Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Transmembrane Signaling Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Skeletal Muscle Contraction Cation Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Ion Transmembrane Transport Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Nervous System Process Musculoskeletal Movement Neuromuscular Process Excitatory Postsynaptic Potential Neuron Cellular Homeostasis	Skeletal Muscle Contraction Cation Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Ion Transmembrane Transport Regulation Of Membrane Potential Skeletal Muscle Tissue Growth Nervous System Process Musculoskeletal Movement Neuromuscular Process Excitatory Postsynaptic Potential
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Drugs		Lamotrigine Agmatine
Diseases		Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)	Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
GWAS		Atrial fibrillation ( 29892015)	Brain lesion load ( 19010793) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: CHRND CHRNE CHRNG ITGA7 LILRB3	2 interacting genes: CHRNA1 GRB2
Entrez ID		1134	1144
HPRD ID		00007	01516
Ensembl ID		ENSG00000138435	ENSG00000135902
Uniprot IDs		P02708 Q53SH4	B4E3W4 Q07001
PDB IDs		1Y5P 1Y5T 1Y6C 4ZJS 5HBT
Enriched GO Terms of Interacting Partners?
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