CHRNA1 and LILRB3

Data Source:
BioGRID (two hybrid)

		CHRNA1	LILRB3
Description		cholinergic receptor nicotinic alpha 1 subunit	leukocyte immunoglobulin like receptor B3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane	Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane
	Molecular Function	Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Skeletal Muscle Contraction Cation Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Ion Transmembrane Transport Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Nervous System Process Musculoskeletal Movement Neuromuscular Process Excitatory Postsynaptic Potential Neuron Cellular Homeostasis	Adaptive Immune Response Defense Response Cell Surface Receptor Signaling Pathway Neutrophil Degranulation Negative Regulation Of Osteoclast Differentiation
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Lamotrigine Agmatine
Diseases		Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
GWAS		Atrial fibrillation ( 29892015)	Birth weight ( 31043758) Takayasu arteritis ( 25604533)
Interacting Genes		5 interacting genes: CHRND CHRNE CHRNG ITGA7 LILRB3	3 interacting genes: CHRNA1 GRID1 RPL38
Entrez ID		1134	11025
HPRD ID		00007	11995
Ensembl ID		ENSG00000138435	ENSG00000204577
Uniprot IDs		P02708 Q53SH4
PDB IDs		1Y5P 1Y5T 1Y6C 4ZJS 5HBT
Enriched GO Terms of Interacting Partners?
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