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CIT and RAC1
Data Source:
BioGRID
(far western blotting)
CIT
RAC1
Description
citron rho-interacting serine/threonine kinase
Rac family small GTPase 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Membrane
Golgi Membrane
Cytoplasm
Endoplasmic Reticulum Membrane
Trans-Golgi Network
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Cell Cortex
Membrane
Lamellipodium
Secretory Granule Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cytoplasmic Vesicle
Ruffle Membrane
Cytoplasmic Ribonucleoprotein Granule
Melanosome
Cell Projection
Dendritic Spine
Intracellular Membrane-bounded Organelle
Recycling Endosome Membrane
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Ficolin-1-rich Granule Membrane
Molecular Function
Transcription Coactivator Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
SH3 Domain Binding
Protein Kinase Binding
PDZ Domain Binding
Protein Serine/threonine Kinase Inhibitor Activity
Metal Ion Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
GTPase Activity
Protein Binding
GTP Binding
Enzyme Binding
Protein Kinase Binding
Thioesterase Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Rho GDP-dissociation Inhibitor Binding
ATPase Binding
Biological Process
Mitotic Cell Cycle
Mitotic Cytokinesis
Peptidyl-threonine Phosphorylation
Actomyosin Structure Organization
Positive Regulation Of Cytokinesis
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Generation Of Neurons
Neuron Apoptotic Process
Negative Regulation Of Protein Serine/threonine Kinase Activity
Neuron Migration
Positive Regulation Of Protein Phosphorylation
Mast Cell Chemotaxis
Sphingosine-1-phosphate Receptor Signaling Pathway
Inflammatory Response
Actin Filament Organization
Cell Adhesion
Cell-matrix Adhesion
Establishment Or Maintenance Of Cell Polarity
Blood Coagulation
Motor Neuron Axon Guidance
Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Cell Size
Response To Wounding
Anatomical Structure Morphogenesis
Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of Lamellipodium Assembly
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Fibroblast Migration
Positive Regulation Of Cell-substrate Adhesion
Rac Protein Signal Transduction
Cell Projection Assembly
Lamellipodium Assembly
Actin Cytoskeleton Organization
Actin Filament Polymerization
Regulation Of Cell Migration
Cortical Cytoskeleton Organization
Positive Regulation Of Microtubule Polymerization
T Cell Costimulation
Ruffle Organization
Negative Regulation Of Interleukin-23 Production
Regulation Of Actin Cytoskeleton Organization
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Rho Protein Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neutrophil Degranulation
Engulfment Of Apoptotic Cell
Regulation Of Nitric Oxide Biosynthetic Process
Bone Resorption
Positive Regulation Of DNA Replication
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Negative Regulation Of Receptor-mediated Endocytosis
Cell Motility
Regulation Of Defense Response To Virus By Virus
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Localization Within Membrane
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Respiratory Burst
Cellular Response To Mechanical Stimulus
Semaphorin-plexin Signaling Pathway
Positive Regulation Of Neutrophil Chemotaxis
Ruffle Assembly
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Neutrophil Migration
Pathways
RHO GTPases activate CIT
RHO GTPases activate CIT
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Nef and signal transduction
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
FCERI mediated MAPK activation
DSCAM interactions
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
PCP/CE pathway
Sema4D mediated inhibition of cell attachment and migration
DCC mediated attractive signaling
DCC mediated attractive signaling
Activation of RAC1
Inactivation of CDC42 and RAC1
VEGFA-VEGFR2 Pathway
Signal transduction by L1
VEGFR2 mediated vascular permeability
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate CIT
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
RHO GTPases Activate NADPH Oxidases
MAPK6/MAPK4 signaling
Neutrophil degranulation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
NTRK2 activates RAC1
Activated NTRK2 signals through CDK5
Activation of RAC1 downstream of NMDARs
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
WNT5:FZD7-mediated leishmania damping
Factors involved in megakaryocyte development and platelet production
Drugs
Fostamatinib
Dextromethorphan
Azathioprine
Guanosine-5'-Diphosphate
Diseases
GWAS
Number of sexual partners (
30643258
)
Urgency urinary incontinence (
25524241
)
Apolipoprotein A1 levels (
32203549
)
Basal cell carcinoma (
31174203
)
Body mass index (
26426971
)
Coronary artery disease (
29212778
)
Keratinocyte cancer (MTAG) (
31174203
)
LDL cholesterol levels (
32203549
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Red cell distribution width (
27863252
)
Interacting Genes
10 interacting genes:
DISC1
DLG4
GRIN1
GRIN2D
MTNR1A
RAC1
RHOA
RHOB
RHOC
RND3
182 interacting genes:
ACTA1
ACTB
AGAP1
AGAP2
AKT1
ARAP1
ARAP2
ARFIP2
ARHGAP1
ARHGAP12
ARHGAP15
ARHGAP17
ARHGAP20
ARHGAP22
ARHGAP23
ARHGAP27
ARHGAP31
ARHGAP32
ARHGAP33
ARHGAP35
ARHGAP39
ARHGAP4
ARHGAP44
ARHGAP9
ARHGDIA
ARHGDIB
ARHGDIG
ARHGEF10
ARHGEF2
ARHGEF25
ARHGEF26
ARHGEF4
ARHGEF7
ARL2BP
BAG6
BAIAP2
BCR
BIRC2
BRINP1
CASP3
CASP7
CAV1
CDC23
CDC42BPG
CDC42SE1
CDC42SE2
CFAP36
CHN1
CHN2
CIT
COG5
CORO1C
CSN2
CYBA
CYBB
CYFIP1
DEF6
DIAPH1
DIAPH3
DMPK
DNMBP
DOCK1
DOCK2
DOCK3
DOCK7
DOCK8
DVL1
DVL2
EIF2AK2
ENAH
FAM13A
FAM13B
FGD5
FHOD1
FLNA
FMN2
FMNL1
GMIP
GRN
HACD3
HACE1
HDAC7
HPS4
ICMT
IFNGR1
IL1RAP
IQGAP1
IQGAP2
KPNA4
KPNA6
KRT40
KTN1
LATS1
LRP2
LTBP3
LTBP4
LZTS2
MAGI1
MAP3K10
MAP3K11
MAP3K4
MCF2
MCF2L
MCM3AP
MDFI
METAP2
MT-CO3
MTNR1A
MYD88
MYH9
NCF2
NCK1
NCKAP1
NEDD4
NME1
NOS2
NOXA1
NR2C2
OCRL
OPHN1
PAK1
PAK2
PAK3
PAK5
PAK6
PARD6A
PARD6B
PARD6G
PIAS3
PIK3R1
PIP4K2A
PLD1
PLEKHG1
PLEKHG2
PLEKHG6
PLXNB1
PPP2R2B
PREX1
PREX2
PRKCA
PRKCD
PRKCI
PRKN
PRMT6
PTK2
RACGAP1
RALBP1
RAP1GDS1
RASGRF1
RASGRF2
RCC2
RGL2
RPS6KB1
SET
SFPQ
SH3BP1
SH3RF1
SH3RF3
SNX31
SRGAP1
SRGAP3
STAT1
STAT3
STAU1
SYDE2
SYNJ2
TBC1D3F
TIAM1
TLR2
TNFRSF12A
TRIO
TUBA4A
UBC
UNKL
USH1C
USP6
VAV1
VAV2
VAV3
VWF
WAS
WASF1
Entrez ID
11113
5879
HPRD ID
09289
03627
Ensembl ID
ENSG00000122966
ENSG00000136238
Uniprot IDs
O14578
A4D2P0
A4D2P1
P63000
PDB IDs
1E96
1FOE
1G4U
1HE1
1HH4
1I4D
1I4L
1I4T
1MH1
1RYF
1RYH
2FJU
2H7V
2NZ8
2P2L
2RMK
2VRW
2WKP
2WKQ
2WKR
2YIN
3B13
3BJI
3RYT
3SBD
3SBE
3SU8
3SUA
3TH5
4GZL
4GZM
4YON
5FI0
5HZH
5N6O
5O33
5QQD
5QQE
5QQF
5QQG
5QQH
5QQI
5QQJ
5QQK
5QQL
5QQM
5QQN
5QU9
6AGP
6BC1
6TGC
Enriched GO Terms of Interacting Partners
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