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CIT and RHOB
Data Source:
BioGRID
(far western blotting, two hybrid)
CIT
RHOB
Description
citron rho-interacting serine/threonine kinase
ras homolog family member B
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Membrane
Nucleus
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Cell Cortex
Endosome Membrane
Cytoplasmic Vesicle
Late Endosome Membrane
Cleavage Furrow
Cell Projection
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Transcription Coactivator Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
SH3 Domain Binding
Protein Kinase Binding
PDZ Domain Binding
Protein Serine/threonine Kinase Inhibitor Activity
Metal Ion Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein Kinase Binding
Biological Process
Mitotic Cell Cycle
Mitotic Cytokinesis
Peptidyl-threonine Phosphorylation
Actomyosin Structure Organization
Positive Regulation Of Cytokinesis
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Generation Of Neurons
Neuron Apoptotic Process
Negative Regulation Of Protein Serine/threonine Kinase Activity
Mitotic Cytokinesis
Angiogenesis
Intracellular Protein Transport
Apoptotic Process
Actin Filament Organization
Cell Adhesion
Establishment Or Maintenance Of Cell Polarity
G Protein-coupled Receptor Signaling Pathway
Rho Protein Signal Transduction
Endosome To Lysosome Transport
Regulation Of Cell Shape
Positive Regulation Of Endothelial Cell Migration
Cell Migration
Cell Differentiation
Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Cortical Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Apoptotic Process
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Regulation Of Small GTPase Mediated Signal Transduction
Endothelial Tube Morphogenesis
Cellular Response To Hydrogen Peroxide
Cellular Response To Ionizing Radiation
Pathways
RHO GTPases activate CIT
RHO GTPases activate CIT
GPVI-mediated activation cascade
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins
RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Fostamatinib
Botulinum toxin type A
Diseases
GWAS
Number of sexual partners (
30643258
)
Urgency urinary incontinence (
25524241
)
Systemic sclerosis (
21750679
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Interacting Genes
10 interacting genes:
DISC1
DLG4
GRIN1
GRIN2D
MTNR1A
RAC1
RHOA
RHOB
RHOC
RND3
12 interacting genes:
ARHGDIG
ARHGEF3
CIT
FNTA
MAP1A
NEDD4L
PDE6D
PGGT1B
PPP2CA
RHPN2
SMURF1
TNFAIP1
Entrez ID
11113
388
HPRD ID
09289
01321
Ensembl ID
ENSG00000122966
ENSG00000143878
Uniprot IDs
O14578
P62745
PDB IDs
2FV8
6HXU
6SGE
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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