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UBE2C and UBA1
Data Source:
BioGRID
(enzymatic study, enzymatic study, enzymatic study, pull down)
UBE2C
UBA1
Description
ubiquitin conjugating enzyme E2 C
ubiquitin like modifier activating enzyme 1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosomal Membrane
Cytosol
Endosome Membrane
Desmosome
Rough Endoplasmic Reticulum Membrane
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
RNA Binding
Ubiquitin Activating Enzyme Activity
Protein Binding
ATP Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Exit From Mitosis
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Protein Ubiquitination
Protein Phosphopantetheinylation
Protein Modification By Small Protein Conjugation
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Hexatantalum Dodecabromide
Quercetin
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Height (
31562340
)
Interacting Genes
33 interacting genes:
ANAPC11
ANAPC2
AURKA
CCNA2
CCNB1
CDC20
CKAP2
CXCR1
DTX1
ENO2
FBXO5
FZR1
GMNN
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
PTTG1
RAG1
RELA
RNF31
RNF7
TNNC1
TRIM21
TRIM28
TRIM29
TRIM72
UBA1
UBASH3B
UBE3D
51 interacting genes:
ABCF1
BUB3
CDC34
CDK1
CHEK1
ECHS1
GAN
GRB2
HGS
HSPH1
LINC01554
MGMT
MTNR1A
PIAS3
SEMA3F
SMAD5
SUMO2
TAF9
TMCC2
TSSC4
TTC19
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L1
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2Q2
UBE2R2
UBE2S
UBE2T
UBE2U
UBE2W
UBE2Z
UBTD2
Entrez ID
11065
7317
HPRD ID
05717
02440
Ensembl ID
ENSG00000175063
ENSG00000130985
Uniprot IDs
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
A0A024R1A3
P22314
PDB IDs
1I7K
4YII
5A31
5KHR
5L9U
4P22
6DC6
Enriched GO Terms of Interacting Partners
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