UBA1 and ABCF1

Data Source:
BioGRID (enzymatic study)

		UBA1	ABCF1
Description		ubiquitin like modifier activating enzyme 1	ATP binding cassette subfamily F member 1
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Nuclear Envelope Nucleoplasm Cytosol Membrane
	Molecular Function	RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding	RNA Binding Protein Binding ATP Binding Translation Factor Activity, RNA Binding ATPase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation	Translation Inflammatory Response Transmembrane Transport
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	ABC-family proteins mediated transport
Drugs		Hexatantalum Dodecabromide Quercetin
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) General cognitive ability ( 29844566) IgM levels ( 28628107) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		51 interacting genes: ABCF1 BUB3 CDC34 CDK1 CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2	4 interacting genes: APP EIF6 SUMO2 UBA1
Entrez ID		7317	23
HPRD ID		02440	09139
Ensembl ID		ENSG00000130985	ENSG00000204574
Uniprot IDs		A0A024R1A3 P22314	A0A1U9X609 Q2L6I2 Q8NE71
PDB IDs		4P22 6DC6	5ZXD
Enriched GO Terms of Interacting Partners?
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