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UBA1 and UBE2B
Data Source:
BioGRID
(enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down)
UBA1
UBE2B
Description
ubiquitin like modifier activating enzyme 1
ubiquitin conjugating enzyme E2 B
Image
GO Annotations
Cellular Component
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosomal Membrane
Cytosol
Endosome Membrane
Desmosome
Rough Endoplasmic Reticulum Membrane
Extracellular Exosome
Chromatin
XY Body
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Plasma Membrane
HULC Complex
Molecular Function
RNA Binding
Ubiquitin Activating Enzyme Activity
Protein Binding
ATP Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Protein Ubiquitination
Protein Phosphopantetheinylation
Protein Modification By Small Protein Conjugation
Protein Polyubiquitination
In Utero Embryonic Development
DNA Repair
Postreplication Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Sperm Axoneme Assembly
Response To UV
Positive Regulation Of Reciprocal Meiotic Recombination
Protein Ubiquitination
Histone Ubiquitination
Negative Regulation Of Histone Phosphorylation
Histone H2A Ubiquitination
Response To Drug
DNA Damage Response, Detection Of DNA Damage
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of CAMP-mediated Signaling
Meiotic Telomere Clustering
Protein Stabilization
Chiasma Assembly
Protein Autoubiquitination
Histone Lysine Demethylation
Synaptonemal Complex Organization
Protein K63-linked Ubiquitination
Heterochromatin Maintenance
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Recognition of DNA damage by PCNA-containing replication complex
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Hexatantalum Dodecabromide
Quercetin
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Relative amplitude of rest-activity cycles (
30120083
)
Interacting Genes
51 interacting genes:
ABCF1
BUB3
CDC34
CDK1
CHEK1
ECHS1
GAN
GRB2
HGS
HSPH1
LINC01554
MGMT
MTNR1A
PIAS3
SEMA3F
SMAD5
SUMO2
TAF9
TMCC2
TSSC4
TTC19
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L1
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2Q2
UBE2R2
UBE2S
UBE2T
UBE2U
UBE2W
UBE2Z
UBTD2
25 interacting genes:
BIRC2
CBX5
CDKN1B
CNOT4
CRMP1
CTNNB1
H2AC20
HERPUD2
MED31
PCNA
PRKN
RAD18
RC3H1
RC3H2
RNF20
RNF4
RNF40
TRIM14
TRIM45
UBA1
UBR1
UBR2
UBR3
UBR5
UNC119
Entrez ID
7317
7320
HPRD ID
02440
01533
Ensembl ID
ENSG00000130985
ENSG00000119048
Uniprot IDs
A0A024R1A3
P22314
P63146
PDB IDs
4P22
6DC6
1JAS
1NXA
2Y4W
2YB6
2YBF
Enriched GO Terms of Interacting Partners
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