PRDX3 and MAP3K13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		PRDX3	MAP3K13
Description		peroxiredoxin 3	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Early Endosome Cytosol Protein-containing Complex	Cytoplasm Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Thioredoxin Peroxidase Activity Alkyl Hydroperoxide Reductase Activity Kinase Binding Protein Kinase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding IkappaB Kinase Complex Binding
	Biological Process	Maternal Placenta Development Apoptotic Process Response To Oxidative Stress Mitochondrion Organization Positive Regulation Of Cell Population Proliferation Peptidyl-cysteine Oxidation Myeloid Cell Differentiation Response To Lipopolysaccharide Negative Regulation Of Kinase Activity Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Redox Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Mitochondrial Membrane Potential Cellular Oxidant Detoxification	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Positive Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Detoxification of Reactive Oxygen Species
Drugs			Fostamatinib
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779)	Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822)
Interacting Genes		15 interacting genes: CDC42 CUL4B FANCC GORASP2 HNRNPD MAGEA11 MAP3K13 NEK6 NR3C1 PRDX4 PTEN RPS6KC1 SUMO4 TNFRSF1A ZNF77	8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		10935	9175
HPRD ID		05305	05372
Ensembl ID		ENSG00000165672	ENSG00000073803
Uniprot IDs		A0A384MTR2 P30048	O43283
PDB IDs		5JCG 5UCX
Enriched GO Terms of Interacting Partners?
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